摘要
目的探讨腹腔镜和开腹子宫肌瘤切除手术对机体CRP、TNF-α、IL-6的影响。方法选取我院收治的110例子宫肌瘤并行手术治疗患者,根据其不同的手术方式将其分为腹腔镜组以及开腹手术组,每组55例,比较两组患者的手术时间、出血量、排气时间、并发症情况及术前术后的CRP、TNF-α、IL-6水平变化情况。结果腹腔镜组患者的手术时间明显长于开腹手术组,但术中出血少、术后排气快,组间比较差异有统计学意义(P<0.05),术前两组患者的血清CRP、TNF-α、IL-6水平比较差异无统计学意义(P>0.05),且两组术前TNF-α均明显高于正常值,术后90min两组CRP、TNF-α、IL-6水平均达到最高峰,腹腔镜手术后CRP、TNF-α、IL-6指标于术后第3d恢复正常,而开腹手术组患者术后第7d才恢复至正常水平,且手术开始后90min、术后第1、3d两组患者CRP、TNF-α、IL-6指标比较差异具有统计学意义(P<0.05)。结论与开腹手术相比,腹腔镜子宫肌瘤切除术所带来的创伤更小、有利于患者的术后康复,有效减少术后并发症,而其可能与腹腔镜手术所导致的机体抗炎因子分泌减少有关。
Objective To investigate the effect of laparoseopic and open operation on serum levels of CRP,TNF- and IL-6 in patients with uterine leiomyoma. Methods 110 cases of patients with uterine leiomyoma based on the ways of operation were divided into laparoseopie group and laparotomy group, 55 cases in each group. The time of surgery, bleeding volume, the exhaust time, complications in both groups were recorded, and the serum CRP,TNF-A and IL-6 levels before and after operation were detected in both groups. Results The operation time in the laparoscopic group was significantly longer than that of the laparotomy group （ P 〈 0.05 ）, but had intraoperative hemorrhage with fast postoperative exhaust. There was no significant difference on serum CRP, TNF alpha and IL-6 levels before operation between two groups （P 〉 0.05 ）. The serum CRP,TNF alpha and IL-6 levels at 90 minutes after operation in both group reached the highest level. The serum CRP,TNF alpha and IL-6 levels in laparoscopic surgery group returned to normal at 3 days post operation, while it took 7 days for laparotomy group. There was significantly difference on the serum CRP,TNF alpha and IL-6 levels between two groups at 90 min, one and three days post operation （ P 〈 0.05 ）. Conclusion Compared with open surgery, laparoseopie myomectomy has fewer traumas with easy rehabilitation and reducing complications postoperative. The laparoseopic surgery might result the body＇s anti-inflammatory factor secretion decreased.
出处
《标记免疫分析与临床》
CAS
2015年第9期909-911,共3页
Labeled Immunoassays and Clinical Medicine
关键词
腹腔镜
子宫肌瘤
开腹
细胞因子
Laparoscopic
Uterine myoma
Laparotomy
Cytokine
