摘要
microRNA是一类内生的、长约22个核苷酸左右的非编码小分子RNA,主要通过结合其靶基因的3'UTR(非翻译区),从而降解靶基因mRNA或抑制其蛋白翻译。microRNA通过基因切割和翻译抑制的方式直接调控基因组中30%以上的蛋白编码基因表达。银屑病以过度增殖和异常分化的角质形成细胞为显著特征,角质形成细胞的上述病理改变被认为起始于细胞免疫系统,T细胞、树突细胞和多种免疫相关细胞因子均牵涉其中。而microRNA几乎参与上述整个病理过程,并发挥重要作用。且microRNA表达的特异性和时序性与证候的动态时空特性极其相似。将microRNA引入银屑病中医证候研究,为从转录后水平阐明银屑病中医证候实质提供新的视角。
MicroRNA is a small non-coding endogenous RNA molecule which is consisted of approximately 22 nucleotides. It de- generate target gene mRNA or suppress its protein translation through integration with the 3＇UTR of the target gene. MicroRNA reg- ulates over 30% of protein coding genetic expression of the genome by cleavage and translation suppression. Keratinocyte cell pro- liferation and abnormal differentiation are the key characteristics of psoriasis, and these pathological changes are thought to origi- nate from cell immune system. T cell, dendritic cell and multiple immune-related cell factors were all involved. MicroRNA partici- pates in throughout the pathological process and plays an important role. MicroRNA expression specificity and sequence shows great similarity with the temporal-spatial characteristic of the syndrome. Introducing mircoRNA into psoriasis TCM syndrome re- search provides a new aspect to the topic through the interpretation of post-transcriptional level.
出处
《世界中医药》
CAS
2015年第8期1270-1275,共6页
World Chinese Medicine
基金
2013年国家自然科学基金项目"新型T辅助细胞亚群Th17
Th22及效应因子IL-22与银屑病辨证论治关系的研究"(编号:81273755)
作者简介
通信作者：段行武（1965．7-），男，博士研究生学历，主任医师、教授，皮肤科主任，研究方向：中医药治疗银屑病、硬皮病，E-mml：xwduan@si-na．com
