摘要
目的探讨急性脑梗死患者的梗死面积与血清超敏C反应蛋白(hs-CRP)和同型半胱氨酸(Hcy)水平的相关性。方法选取于本院神经内科住院的急性脑梗死患者112例,对纳入研究患者于24h内进行磁共振检查,将患者按脑梗死面积大小分为大面积脑梗死组和小面积脑梗死组(各56例)。收集两组患者的年龄、性别、吸烟、饮酒、高血压、高血脂及糖尿病方面的一般性资料,检测患者血清hs-CRP、Hcy水平,对两组的一般资料和检测数据进行比较、分析。结果两组患者年龄及饮酒、吸烟、高血压、高血脂比例进行比较,差异均无统计学意义(P>0.05)。小面积脑梗死组患者hs-CRP、Hcy、血糖水平均低于大面积脑梗死组(P<0.05),并且脑梗死面积与血清hs-CRP、Hcy水平及血糖水平呈正相关(r分别为0.625、0.833、0.651,P<0.05)。结论血清hs-CRP、Hcy水平是急性脑梗死患者动脉粥样硬化斑块形成的危险因素,其血清水平的高低有助于脑梗死面积的预测,糖尿病是脑梗死的重要诱因。
Objective To study the correlation among acute cerebral infarction area ,serum high sensitivity C reactive protein（hs‐CRP）andhomocysteine（Hcy）concentrations.Methods 112acutecerebralinfarctionpatientsreceivedinneurologicaldepartment of the hospital were enrolled in the study .They were divided into small infarction size group（n=56） and large infarction size group （n=56） ,according to the cerebral infarction area determined by using MRI and MRA .Common information of patients such as age , sex ,smoking ,drinking ,hypertension ,hyperlipidemia and diabetes history were recorded ,serum hs‐CRP and Hcy concentrations were also determined .The comparison between the 2 groups were performed on those common information and test results .Results There was no statistically significant difference on age ,alcohol consumption ,smoking ,hypertension and high cholesterol between the two groups（P〉0 .05） .Serum concentrations of hs‐CRP ,Hcy and blood glucose in small infarction size group were lower than those in large infarction size group（P〈0 .05） ,and the infarct areas were positively correlated with hs‐CRP ,Hcy and blood glucose levels（r=0 .625 ,0 .833 ,0 .651 ,P〈0 .05） .Conclusion Serum hs‐CRP ,Hcy level are high risk factor for atherosclerosis plaque for‐mation of acute cerebral infarction patients ,the serum levels help predict the infarction area ,and diabetes is an important cause of cerebral infarction .
出处
《国际检验医学杂志》
CAS
2015年第17期2490-2491,2494,共3页
International Journal of Laboratory Medicine
基金
南京市卫生青年人才项目(QRX11115)
关键词
脑梗死面积
超敏C反应蛋白
同型半胱氨酸
cerebral infarction
high sensitivity C reactive protein
homocysteine
作者简介
阮桂琴，女，主管技师，主要从事精神、神经疾病相关临床检验的研究。
通讯作者，E-mail：hql_nju@163．com
