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利拉鲁肽治疗2型糖尿病的研究进展 被引量:4

Progress on the Application of Liraglutide Treatment of Diabetes
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摘要 利拉鲁肽是一种胰高糖素样肽-1(GLP-1)类似物,作为一种新型的2型糖尿病治疗药物,具有降低体质量、改善胰岛β细胞功能、降低收缩压,减少低血糖发生率的作用。本文通过对近期国内外文献中关于利拉鲁肽研究进展的归纳和分析,从其药理作用研究、动物实验研究、临床研究、安全性和耐受性等方面进行阐述,为今后的研究提供参考和依据。 Liraglutide is a glucagon-like peptide -1 (GLP-1) analogue, as a new type 2 diabetes drug, with lower body mass, improve islet β-cell function, reduced systolic blood pressure reduce the incidence of hypoglycemia role. Based on the recent literature are summarized and analyzed with regard to the progress Of liraglutide, its pharmacological effects, animal studies, clinical studies, the safety and tolerability aspects elaborated to provide a reference for future research and basis.
出处 《现代生物医学进展》 CAS 2015年第19期3777-3778,3783,共3页 Progress in Modern Biomedicine
基金 国家自然科学基金项目(30871165)
关键词 利拉鲁肽 降糖药物 2型糖尿病 Liraglutide Hypoglycemic drugs Type 2 diabetes
作者简介 作者简介:王晓茜(1970-),女,副主任医师,主要研究方向:糖尿病、代谢综合征,E-mail:wxxi_wxxi@163.com
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  • 1Buturovic BA,Ristic LB,Narancic AM.Effects of Teraphy with Basal Insulin Analogues Combined with GLP 1 Analogues and Metformin in the Treatment of Obese Patients with Poorly Regulated Postprandial Glycemia[J].Med Arch,2014,68(5):313-316.
  • 2Jeon WS,Park CY.Antiobesity pharmacotherapy for patients with type 2 diabetes:focus on long-term management[J].Endocrinol Metab(Seoul),2014,29(4):410-417.
  • 3Johnston SS,Nguyen H,Felber E,et al.Retrospective Study of Adherence to Glucagon-like Peptide-1 Receptor Agonist Therapy in Patients with Type 2 Diabetes Mellitus in the United States[J].Adv Ther,2014,31(11):1119-1133.
  • 4Araki H,Tanaka Y,Yoshida S,et al.Oral glucose-stimulated serum C-peptide predicts successful switching from insulin therapy to liraglutide monotherapy in Japanese patients with type 2 diabetes and renal impairment[J].J Diabetes Investig,2014,5(4):435-441.
  • 5Osonoi T,Saito M,Tamasawa A,et al.Effect of hemodialysis on plasma glucose profile and plasma level of liraglutide in patients with type 2 diabetes mellitus and end-stage renal disease:a pilot study[J].PLo S One,2014,9(12):e113468.
  • 6Dharmalingam M.Efficacy and tolerability of GLP-1 agonists in patients with type 2 diabetes mellitus:an Indian perspective[J].Ther Adv Endocrinol Metab,2014,5(6):159-165.
  • 7Kimura T,Kaneto H,Shimoda M,et al.Protective effects of pioglitazone and/or liraglutide on pancreaticβ-cells in db/db mice:Comparison of their effects between in an early and advanced stage of diabetes[J].Mol Cell Endocrinol,2015,15(400):78-89.
  • 8Ando T,Haraguchi A,Matsunaga T,et al.Liraglutide as a potentially useful agent for regulating appetite in diabetic patients with hypothalamic hyperphagia and obesity[J].Intern Med,2014,53(16):1791-1795.
  • 9Trujillo JM,Nuffer W.Albiglutide:a new GLP-1 receptor agonist for the treatment of type 2 diabetes[J].Ann Pharmacother,2014,48(11):1494-1501.
  • 10Nyeland ME,Ploug UJ,Richards A,et al.Evaluation of the effectiveness of liraglutide and sitagliptin in type 2 diabetes:a retrospective study in UK primary care[J].Int J Clin Pract,2014,10[Epub ahead of print].

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