摘要
目的探讨阿托伐他汀联合苯磺酸氨氯地平治疗冠心病合并脑梗死的临床疗效及对血脂水平的影响。方法将72例冠心病合并脑梗死患者随机分为观察组和对照组,每组36例。对照组给予苯磺酸氨氯地平进行治疗,观察组给予阿托伐他汀联合苯磺酸氨氯地平进行治疗。治疗4周后,比较2组临床疗效及不良反应的发生情况,并观察治疗前后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平的变化。结果观察组总有效率(88.9%)显著高于对照组(66.7%),而不良反应总发生率显著低于对照组,差异均有统计学意义(P<0.05或P<0.01)。治疗后,观察组TC、TG及LDL-C水平较治疗前明显下降(P<0.05),HDL-C水平明显升高(P<0.01),而对照组无明显变化;观察组治疗后TC、TG及LDL-C水平显著低于对照组,而HDL-C水平显著高于对照组,差异均有统计学意义(P<0.05或P<0.01)。结论阿托伐他汀联合苯磺酸氨氯地平能有效改善冠心病合并脑梗死患者的血脂水平,疗效显著,且安全性高。
Objective To investigate the clinical efficacy o{ atorvastatin and amlodipine be- sylate for coronary heart disease （CHD） complicated by cerebral infarction and its effect on blood lipids. Methods Seventy-two patients with CHD complicated by cerebral infarction were randomly divided into observation group and control group, 36 cases in each group. Control group was given amlodipine besylate, while observation group given atorvastatin and amlodipine besylate. 4 weeks after treatment, the clinical efficacy and adverse reactions in two groups were compared, and the changes of total cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C） levels were observed. Results The overall re- sponse rate in observation group （88.9 % ） was higher than control group （66.7 % ）, but the inci- dence of adverse reactions lower than control group, both differences were statistically significant （P 〈0.05 or P〈0.01）. Compared with treatment before, the levels of TC, TG and LDL-C went down obviously （ P 〈 0.05 ） and HDL-C level up （P 〈 0.01 ） in observation group after treatment, but no significant change occurred in control group. The levels of TC, TG and LDL-C in observa- tion group after treatment were lower than control group, but HDL-C level higher than control group, with statistical significance （ P 〈 0.05 or P 〈 0.01 ）. Conclusion Atorvastatin combined with amlodipine besylate can effectively ameliorate the blood lipids of patients with CHD complicated by cerebral infarction, with significant efficacy and high safety.
出处
《实用临床医药杂志》
CAS
2015年第15期8-10,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11522917)
关键词
阿托伐他汀
苯磺酸氨氯地平
冠心病
脑梗死
atorvastatin
amlodipine besylate
coronary heart disease
cerebral infarction
