摘要
目的:研究IL-6水平检测与重症并发感染者的相关性。方法:选择2013年1月-2014年12月本院接诊的73例重症患者(APACHEⅡ评分>12),按照是否并发感染分为重症并发感染组(41例)和重症非并发感染组(32例),并随机从本院健康体检的人群中选择30例正常者作为对照组,使用放射免疫分析法测定三组血清IL-6水平,比较并分析IL-6水平与APACHEⅡ评分的相关性。结果:重症非并发感染组患者的血清IL-6水平(131.25±51.82)pg/m L明显高于对照组(83.98±31.15)pg/m L,重症并发感染组的血清IL-6水平(154.08±53.06)pg/m L亦明显高于对照组,比较差异均有统计学意义(P<0.05);但重症非并发感染组的血清IL-6水平与重症并发感染组比较,差异无统计学意义(P>0.05)。重症非并发感染组患者的血清IL-6水平与其APACHEⅡ评分呈正相关关系(r=0.793,P=0.0004);重症并发感染组患者的血清IL-6水平与其APACHEⅡ评分亦呈正相关关系(r=0.864,P=0.0001)。重症非并发感染组和并发感染组血清IL-6阳性率均明显高于对照组,比较差异均有统计学意义(P<0.05)。结论:重症患者无论是否并发感染,其血清IL-6水平均显著升高,且IL-6水平升高程度与患者损伤的严重程度呈正相关。
Objective： To research the relevance of IL-6 levels and severely infected person with infection. Method： 73 severe illness patients （ APACHE Ⅱ score〉12 ） from January 2013 to December 2014 in our hospital were selected and divided, according to whether concurrent infection complicated, into severe infection group （ 41 cases ） and non-concurrent infection group （ 32 cases ）, and 30 normal healthy cases were randomly selected from our hospital as control group. The serum IL-6 level was detected by using radioimmunoassay..To compare three groups IL-6 levels and a correlation of IL-6 levels and APACHE Ⅱ scores. Result： The serum IL-6 level of the severe non-concurrent infection group （ 131.25 ± 51.82 ） pg/mL was significantly higher than that of the control group （ 83.98 ± 31.15 ） pg/mL, and the difference was statistically significant （ P〈0.05 ） . And that of the severe concurrent infection group was （ 154.08 ± 53.06 ） pg/mL, which was significantly higher than that of the control group, the difference was statistically significant （ P〈0.05 ）, too. The difference of serum tL-6 level between the severe non-concurrent infection group and severe concurrent infection group was not significant （ P〉0.05 ） . Serum IL-6 level of the severe non-concurrent infection group and its APACHE Ⅱ score showed a positive correlation （ r=-0.793, P=0.0004 ） . Serum IL-6 level of infected patients with severe concurrent and its APACHE 11 scores were positively correlated （ r=-0.864, P=0.0001 ） . Serum IL-6 positive rate of the infection group was significantly higher than that of the control group, severe concurrent infection serum IL-6 positive rate was significantly higher that of the control group, the difference was statistically significant （ P〈0.05 ） . Conclusion： Whether concurrent infection in critically ill patients, serum IL-6 levels are significantly elevated, and increasing degree of IL 6-levels is positively correlated with severity of patient injury.
出处
《中国医学创新》
CAS
2015年第25期63-66,共4页
Medical Innovation of China
关键词
重症
并发感染
IL-6
Severe
Concurrent infections
IL-6
作者简介
通信作者：誉秀华
