摘要
目的给药方法是影响药物治疗激素性股骨头坏死的重要因素之一,但目前关于不同给药方法的比较和评价研究不多,文中拟从给药顺从性、给药时间及药效学角度评价不同给药方法的效果差异,为选择最佳给药方法提供实验依据。方法将激素性股骨头坏死新西兰雄性兔40只按干预给药方法不同随机分为5组:口腔灌注给药组(n=10)、灌胃给药组(n=10)、自由饮药组(n=10)及模型空白组(n=5)、空白对照组(n=5),比较口腔灌注给药组、灌胃给药组、自由饮药组给药顺从性、给药时间、血脂含量和空骨陷窝率等药效学指标。结果口腔灌注给药组顺从性效应量(1.78±0.64)较灌胃给药组(4.04±0.87)、自由饮药组(8.94±1.05)降低(P﹤0.01);口腔灌注给药组给药时间[(0.94±0.02)min]、灌胃给药组[(9.47±0.31)min]及自由饮药组[(889.50±235.38)min]整体比较逐渐升高(P=0.000),组间两两比较差异有统计学意义(P<0.05)。第2、4周时,口腔灌注给药组、灌胃给药组、自由饮药组的胆固醇、三酰甘油、低密度脂蛋白较模型空白组和空白对照组,差异均有统计学意义(P<0.05),而口腔灌注给药组较自由饮药组,差异亦有统计学意义(P<0.05)。第2周,口腔灌注给药组空骨陷窝率[(15.44±2.68)%]、灌胃给药组[(15.02±3.34)%]、自由饮药组[(16.72±4.06)%]与模型空白组[(18.59±3.12)%]和空白对照组[(10.82±2.76)%]比较,差异均有统计学意义(P<0.05);第4周,口腔灌注给药组空骨陷窝率[(18.53±3.26)%]、灌胃给药组[(18.85±3.17)%]、自由饮药组[(20.41±4.18)%]与模型空白组[(24.66±3.74)%]和空白对照组[(11.37±2.23)%]比较,差异亦均有统计学意义(P<0.05)。结论与传统给药方法相比,经口腔深部灌注给药顺从性更优、给药时间更短,药效学与灌胃给药相似,但较自由饮药给药更为有效,是一种相对更佳的给药方法。
Objective The method of administration is one of the important factors influencing steroid-induced femoral head necrosis （ FHN） .From the perspective of administration compliance, time and persons needed, and pharmacodynamics, this study compared different administration methods for steroid-induced FHN in rabbits aiming to provide some experimental evidence for selec-ting correct methods of administration. Methods The steroid-induced femoral head necrosis rabbits （ New Zealand, male） were ran-domly divided into five groups according to the different administration methods of intervention：deep oral administration group （n=10）, in-tragastric gavage administration group （ n =10 ） , free-drinking drug group （n=10） and model control group （n=5）, blank control group （n=5）, the administration compliance, administration time, mortal-ity, pharmacodynamic index of lipid content and empty lacunae rate were compared among deep oral administration group, intragastric ga-vage administration group, free-drinking drug group. Results Compliance effect size of deep oral administration group （ 1.78 ±＆nbsp;0.64） lower than intragastric gavage administration group （4.04 ±0.87） and free-drinking drug group （8.94 ±1.05） （P〈0.01）. Administration time among deep oral administration group （[0.94 ±0.02]min）, intragastric gavage administration group （[9.47 ± 0.31]min） and free-drinking drug group （[889.50 ±235.38]min） overall comparison gradually increased （P=0.000）, the differ-ence between the two groups was statistically significant （P〈0.05）.At the 2 and 4 weeks, cholesterol, triglycerides and low-density lipoprotein of deep oral administration group, intragastric gavage administration group, free-drinking drug group compared with model control group and blank control group the difference was statistically significant （ P〈0.05） , and deep oral administration group com-pared with free-drinking drug group, the difference was also statistically significant （ P〈0.05） .At the 2 weeks, empty lacunae rate of deep oral administration group （[15.44 ±2.68]%）, intragastric gavage administration group （[15.02 ±3.34]）%）, free-drinking drug group （[16.72 ±4.06]%） compared with model control group （[18.59 ±3.12]%） and blank control group （[10.82 ± 2.76]%, the difference was statistically significant （P〈0.05）.At the 4 weeks, empty lacunae rate of deep oral administration group （[18.53 ±3.26]%）, intragastric gavage administration group （[18.85 ±3.17]%）, free-drinking drug group （[20.41 ±4.18]%） compared with model control group （[24.66 ±3.74]%） and blank control group （[11.37 ±2.23]%）, the difference was also sta-tistically significant （ P〈0.05 ） . Conclusion Compared with traditional methods of administration, deep oral administration has better compliance, shorter administration time, and similar to intragastric gavage administration in pharmacodynamics, but more effec-tive than free-drinking drug administration, and it is a new and effective method of administration.
出处
《医学研究生学报》
CAS
北大核心
2015年第7期745-749,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金(81360224)
关键词
给药方法
口腔灌注给药
灌胃给药
兔
激素性股骨头坏死
Administration method
Gavage administration
Oral administration
Rabbit
Steroid-induced femoral head necrosis
作者简介
医学硕士研究生
通讯作者：赵建民，E—mail：1014519194@qq．com
