摘要
目的探讨分析盐酸司维拉姆联合血液透析对肾性骨病影响的临床效果。方法选取本院2013年6月~2014年6月的90例肾性骨病患者为研究对象,采用随机法将其平均分为对照组A、对照组B和观察组。对照组A给予盐酸司维拉姆进行治疗,对照组B给予血液透析进行治疗,观察组采用盐酸司维拉姆联合血液透析进行治疗。观察3组患者的临床疗效、治疗前后常用生化指标及治疗后的不良反应情况。结果治疗前,3组患者Ca2＋、P3-、钙磷乘积、PTH的水平无明显差异,治疗后3组患者的Ca2＋水平升高,观察组Ca2＋水平显著高于对照组A和对照组B,3组患者的P3-、钙磷乘积、PTH水平均有所下降,观察组P3-、钙磷乘积、PTH水平均明显低于对照组A、B,差异有统计学意义（P〈0.05）;对照组A、对照组B与观察组的临床总有效率分别70.00%、60.00%和93.33%,观察组的有效率明显高于对照组A、B,差异有统计学意义（P〈0.05）;3组患者不良反应的发生率分别为53.33%、56.67%和10.00%,观察组明显低于对照组A、B,差异有统计学意义（P〈0.05）。结论盐酸司维拉姆联合血液透析治疗肾性骨病的临床疗效明显优于单独口服盐酸司维拉姆或采用血液透析进行治疗,两者联合用药的安全性高,值得临床推广应用。
Objective To investigate and analyze the clinical effect of sevelamer hydrochloride combined with hemodialysis in the treatment of renal osteopathy. Methods 90 cases of patients with renal osteodystrophy in our hospital from June 2013 to June 2014 were selected and were randomly divided into control group A,control group B and observation group.The patients in control group A and control group B were respectively treated with sevelamer hydrochlofide and hemodialysis.The patients in observation group were treated with the combination of sevelamer hy- drochloride and hemodialysis.The clinical therapeutic effect,commonly used biochemical indicators before and after treatment and adverse reactions after treatment among three groups of patients was observed respectively. Results The levels of Ca2＋,P3-,calcium-phosphorus product and PTH among three groups of patients didn＇t show obvious difference before treatment.The levels of Ca2＋ among three groups of patients were increased after treatment,and the level of Ca2＋ in observation group was significantly higher than that in control group A and B.The levels of P3-,calcium-phosphorus product and PTH were decreased among three groups of patients,and the levels of P3-,calcium-phosphorus product and PTH in observation group were significantly lower than that in control group A and B,with statistical difference（P〈0.05）. Total clinical efficiencies in control group A,B and observation group were separately 70.00 %,60.00 % and 93.33%. The efficiency in observation group was significantly higher than that in control group A and B,with statistical difference（P〈0.05）.The incidences of adverse reactions among three groups were separately 53.33%,56.67% and 10.00%.The incidence of adverse reaction in observation group was significantly lower than that in control group A and control group B,with statistical difference （P〈0.05）. Conclusion The clinical effect of sevelamer hydrochloride combined with hemodialysis in the treatment of renal osteopathy shows an significant advantage than that of separately oral administration of sevelamer hydrochloride and hemodialysis.The combination of the two drugs is of high security.Therefore,the sevelamer hydrochloride combined with hemodialysis in the treatment of renal osteopathy is worthy of promotion in the clinical practice.
出处
《中国当代医药》
2015年第19期30-32,共3页
China Modern Medicine
关键词
盐酸司维拉姆
血液透析
肾性骨病
临床效果
Evelamer hydrochloride
Hemodialysis
Renal osteopathy
Clinical effect
