摘要
目的观察丹参酮联合依巴斯汀治疗过敏性紫癜的临床疗效及安全性。方法将入选的70例过敏性紫癜患者采用随机数字表法分为两组:治疗组(n=38例)和对照组(n=32例),对照组给予依巴斯汀、潘生丁、维生素C片等治疗,治疗组在对照组的基础上给予加服丹参酮胶囊治疗,疗程均为2周。观察两组治疗后的临床效果。结果治疗两周后,两组皮损评分均较治疗前明显下降(P<0.05),且治疗组皮损评分低于对照组皮损评分,治疗组的有效率(84.21%)明显高于对照组有效率(46.88%),差异均有统计学意义(P均<0.05);两组治疗后均随访半年,与对照组比较,治疗组患者皮损开始消退时间、完全消退时间短,半年复发次数少,复发时间间隔长(P均<0.05)。治疗组1例(3.13%)、对照组2例(5.26%)患者用药后出现不良反应(均为皮肤干燥现象),但均能耐受至治疗完成,两组患者不良反应发生率差异无统计学意义(P>0.05)。结论丹参酮联合依巴斯汀治疗过敏性紫癜疗效较好,不良反应少,值得临床医生选择。
Objective To investigate the efficacy and safety of tanshinone combined with ebastine in treatment of aller- gic purpura. Methods Seventy patients with allergic purpura were randomly divided into two groups by ran- dom number table：treatment group （n = 38 cases） and control group （n = 32 cases） ; control group were given ebastine, dipyridamole and vitamin C, treatment group were treated by tanshinone on the basis of con- trol group; the treatment of two groups continued for 2 successive weeks, meanwhile, its efficacy was ob- served. Results Lesion score of two groups were significantly decreased after two weeks treatment, lesion score of treatment group was lower than that of control group; effectiveness（ 84. 21% ） in treatment group was obviously higher than that in control group （46. 88% ） after two weeks treatment,the difference was statisti- cally significant （ all P 〈 0.05 ） ; all patients were followed up for half a year after treatment. Compared with that of control group, time of lesions began to fade or completely fade in treatment group is earlier; less recur- rence within six months,the recurrence interval was longer（ P 〈 0. 05 ）. Although 1 case of treatment group （3.13 % ） and 2 cases of control group（5.26% ） appeared adverse reactions （slightly dry skin）, both could stand to complete the course of treatment,there was no obvious statistical significance in the incidence of ad- verse reaction between the two groups （P 〈 0.05 ）. Conclusion Tanshinone combined with ebastine is effec- tive in the treatment of allergic purpura and have less adverse reactions, this treatment deserves the further clinical application.
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2015年第7期766-768,共3页
The Chinese Journal of Dermatovenereology
关键词
丹参酮
依巴斯汀
过敏性紫癜
临床观察
Tanshinone
Ebastine
Allergic purpura
Efficacy observation
