摘要
目的 探讨计算机辅助认知训练对精神分裂症患者认知功能康复治疗效果.方法 研究组51例精神分裂症患者,通过计算机辅助认知作业训练治疗2个月,对照组53例精神分裂症患者采用常规工娱疗法治疗2个月.2组患者治疗前后分别进行阳性和阴性症状量表（PANSS）、连线测验A和B、韦氏成人记忆量表（WMS）和威斯康星卡片分类测验（WCST）等神经认知功能测验,并进行统计学分析比较.结果 ①治疗后,研究组和对照组患者临床症状PANSS量表总评分[（59.82±8.41）、（59.45±9.05）分]及阴性症状量表的评分[（16.67±3.20）、（17.08 ±3.23）分]均较组内治疗前[PANSS总评分（70.23±7.62）、（68.32±10.14）分及阴性症状量表评分（21.46±3.26）、（20.82±4.21）分]明显下降,组内差异均有统计学意义（P＜0.05）;研究组治疗后上述各项的减分程度略高于对照组,但组间差异无统计学意义（P＞0.05）.②治疗后,研究组连线测验A测验成绩[（44.14 ±17.51）分]和B测验成绩[（96.47±34.43）分]均较组内治疗前[（51.76±21.18）和（114.31±35.76）分]明显下降（P＜0.01）;而对照组连线测验A测验成绩和B测验成绩治疗前后变化不大（P＞0.05）.③治疗后,研究组WMS再认和WMS再生两个分测验成绩[（8.21±3.96）、（10.24±3.52）分]较组内治疗前[（5.83±3.12）、（8.63±3.45）分]明显增加,差异有统计学意义（P＜0.01）;对照组WMS再认和WMS再生两个分测验成绩治疗前后变化不大（P＞0.05）;研究组测验成绩提高明显好于对照组（P=0.01）.④治疗后,研究组WCST的总测验数、持续错误数、正确数和分类数成绩[（87.82 ±23.21）、（23.20±11.5）、（23.14 ±42.00）、（4.80±0.76）]较组内治疗前[（78.20 ±21.40）、（28.87±10.21）、（21.54 ±26.50）、（4.26±0.08）]明显提高（P＜0.05）;对照组WCST测验总测验、持续错误数、正确数和分类数成绩治疗前后变化不大（P＞0.05）;研究组的测验成绩变化明显大于对照组（P＜0.O1）.结论 计算机辅助认知训练可以提高精神分裂症患者认知功能测验任务成绩,改善患者部分认知领域的功能.
Objective To investigate the effect of computer-assisted cognition training on the cognitive functioning of schizophrenic patients.Methods One hundred and four persons with schizophrenia were randomly divided into a research group of 51 cases and a control group of 53.The former were given computerized cognition training covering attention,memory and executive functions.The training lasted 2 months.The controls received regular occupational and recreational therapy.Before and after the treatment the 2 groups were evaluated using the Positive and Negative Syndrome scale （PANSS）,the Trail Making tests A and B （TMTs）,Wechsler＇s memory scale （WMS） and the Wisconsin card sorting test （WCST）.Results The average total PANSS score of the research group declined significantly from （70.23 ±7.62） before treatment to （59.82 ± 8.41） after treatment;so did that of the control group from （68.32 ± 10.14） to （59.45 ± 9.05）.The average negative symptoms scale score of the treatment group and the control group also decreased significantly for （21.46 ± 3.26） before treatment to （16.67 ±3.20）,and from （20.82 ±4.21） to （17.08 ±3.23） respectively,but there was no significant difference between the groups in the magnitude.The research group＇s average TMT A and TMT B scores also decreased from（51.76±21.18） and （114.31 ±35.76） to （44.14 ±17.51） and （96.47 ±34.43）,while no significant difference was observed before and after the treatment in the control group.The WMS recognition and regeneration scores of the research group improved significantly from （5.83 ± 3.12） and （8.63 ± 3.45） to （8.21 ± 3.96） and （10.24 ±3.52） after intervention,while no improvement was found in the control group.The same trend was observed in the total test number,the continuous error numbers,the correct numbers and the classification number scores in the WCST.Conclusion Computerized cognition training can improve the cognition of persons with schizophrenia to some extent.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2015年第6期440-445,共6页
Chinese Journal of Physical Medicine and Rehabilitation
基金
浙江省医药卫生科学研究基金（2009A172）
杭州市科技局医学重点专科专病专项基金（20091233Q13）和（20120533Q14）共同资助
关键词
精神分裂症
认知疗法
治疗
计算机辅助
认知障碍
Schizophrenia
Cognitive therapy
Computer-assisted therapy
Cognitive disorders
作者简介
刘健，Email：lj7037@126．com
