摘要
目的:分析中医药干预并使肝硬化血小板计数回升的文献报道,总结常用的治则和方药,探索肝硬化患者血小板计数减低的中医病机特点,为治疗肝硬化患者血小板计数减低提供依据。方法:以"肝硬化""血小板""中医"进行全文检索,系统检索了中国知网、万方数据知识服务平台、中文维普科技期刊数据库的期刊文献。依据纳入排除标准,选取符合要求的文献,建立Excel工作表,提取其发表时间、干预对象病情情况(分期、child-pugh分级)、研究应用方剂及中药的名称、治则等。最后,对所提取的内容进行分析、归纳、总结。结果:28篇干预研究可为中医药干预能够使血小板计数回升提供证据,治则以活血化瘀/软肝散结、健脾益气应用最多,常用的具有活血化瘀/软肝散结的中药有当归、鳖甲、丹参等,具有益气健脾作用的中药以黄芪、白术最为常用。结论:瘀血、(脾)气虚是肝硬化患者血小板计数减低的主要病机,通过活血化瘀、健脾益气可以使肝硬化患者血小板计数减低得到改善。
Objective： This article is to analyze the literature report related to Chinese medicine intervention and its promoting effect on thrombocytopenia in patients with liver cirrhosis,to summarize the common treatments and prescriptions,and to explore the pathogenic characteristics of thrombocytopenia in liver cirrhosis from the perspective of TCM,so as to provide a basis for the treatment of thrombocytopenia in liver cirrhosis. Methods： Do full text research in China National Knowledge Internet,Wanfang Data Knowledge Service Platform,and VIP Chinese science and technology periodical database with the keywords ＂liver cirrhosis＂and ＂thrombocyte＂and ＂TCM＂to get periodical literature. Select the satisfactory literature according to inclusion criteria and exclusion criteria,create an excel worksheet,and then extract their pubtime,disease situation of the intervention objects（ staging of disease or The child-pugh）,prescriptions,herbs and rules of treatment in studies and so on. Finally,analyze,generalize and summarize the extracted content. Results： 28 intervention studies have proved that Chinese medicine intervention can improve thrombocytopenia in patients with liver cirrhosis. In these studies,the main treatments include activating blood and dissolving stasis,softening the liver and eliminating stagnation,and strengthening the spleen and replenishing Qi. The commonly-used Chinese herbs to activate blood and dissolve stasis,soften the liver and eliminate stagnation are angelica sinensis,turtle shell,the root of red-rooted salvia,etc. The commonly-used Chinese herbs to strengthen the spleen and replenish Qi are astragalus mongholicus,bighead atractylodes rhizome,etc. Conclusion： Blood stasis and（ Spleen） Qi deficiency are the main pathogenesis of thrombocytopenia in patients with liver cirrhosis. Activating blood and dissolving stasis as well as strengthening the spleen and replenishing Qi can improve thrombocytopenia in patients with liver cirrhosis.
出处
《辽宁中医杂志》
CAS
北大核心
2015年第7期1177-1180,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金青年科学基金项目(81302915)
国家重点基础研究发展计划(973计划)项目(2011CB505105)
北京中医药大学创新团队项目(2011CXTD08)
关键词
肝硬化
中医
血小板
liver cirrhosis
TCM
thrombocyte
作者简介
田露（1988-），女，河北廊坊人，硕士研究生，研究方向：诊法与辨证的规范化、客观化研究。
通讯作者：吴秀艳，E—mail：wuxiuy@163．com；
通讯作者：王天芳，E-mail：tianfangwang2000@163．com。
