摘要
目的探讨联合检测癌胚抗原(CEA)、甲胎蛋白(AFP)、癌糖类相关抗原(CA19-9)对结直肠癌的诊断价值。方法选择广州医科大学附属深圳沙井医院2011年1月—2013年12月收治的60例结直肠癌,观察不同部位、不同分化程度及不同Dukes分期结直肠癌CEA、AFP、CA19-9的表达水平,分析其联合检测对结直肠癌诊断的敏感性和特异度。结果 Dukes C+D期CEA、AFP、CA19-9阳性率高于Dukes A+B期(P<0.01)。CEA、AFP、CA19-9联合检测结直肠癌敏感性均高于单项检测,且3项联合检测在结直肠癌Dukes C+D期的敏感性高于Dukes A+B期(P<0.01),但特异度比较差异无统计学意义(P>0.05)。结论 CEA、AFP、CA19-9联合检测可提高结直肠癌诊断阳性率,且对Dukes C、D期诊断价值较高,有助于判断结直肠癌病理分期、估计预后并指导手术范围。
Objective To study the value of combined detection of carcinoembryonic antigen（CEA）,alpha fetoprotein（ AFP） and carbohydrate antigen 19-9（ CA19-9） in diagnosis of colorectal cancer. Methods A total of 60 colorectal cancer inpatients during January 2011 and December 2013 were recruited in this study,and levels of serum CEA,AFP and CA19-9 expressions of different tumor parts,differentiated degrees and Dukes clinical stages were observed,and then the sensibility and specificity of combined detection for colorectal cancer were analyzed. Results The positive rates of CEA,AFP and CA19-9 in Dukes C ＋ D stage were statistically higher than those in Dukes A ＋ B stage（P〈0. 01）. The combined detection sensitivity of CEA,AFP and CA19-9 in diagnosis of colorectal cancer was stronger than those by CEA,AFP and CA19-9 single detection,and the combined detection sensitivity in Dukes C ＋ D stage was stronger than that in Dukes A ＋ B stage（ P〈0. 01）,but there were no statistically significant in specificity values（ P〉. 05）. Conclusion The combined detection of CA19-9,AFP and CEA can increase the positive rate in diagnosis of colorectal cancer. The diagnosed value of the combined detection in patients with Dukes（ C ＋ D） is high and helpful in judging the pathological stage,assessing prognosis and guiding operational range.
出处
《解放军医药杂志》
CAS
2015年第5期53-55,共3页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词
结直肠癌
癌胚抗原
甲胎蛋白
糖抗原19-9
Colorectal neoplasms
Carcinoembryonic antigen
Alpha-fetoprotein
Carbohydrate antigen 19-9
