摘要
目的探讨家族性甲状腺肿（familialgoiter，FG）的临床表现及治疗。方法回顾性分析2个家系中10例FG患者的临床资料。结果10例FG患者来自2个家系，1例死亡，余多表现为不同程度吞咽不适、通气功能受阻；超声检查显示甲状腺巨大，形态失常、质地坚硬，细胞学检查未发现恶性改变；8例行促甲状腺素抑制治疗无效；4例手术治疗者，其中3例5～6a复发；5例完成2次131I治疗，治疗后血清甲状腺球蛋白水平、甲状腺质量、放射性碘摄入率均较治疗前明显下降，治愈率100％。结论FG临床表现多为吞咽不适、通气功能受阻，131I可有效治疗FG。
Objective To analyze the clinical manifestations and treatment of familiar goiter（FG）.Methods The clinical data of 10 patients with FG from two families were retrospectively analyzed.Results Ten FG patients were from two different families.One patient died.The survived patients were demonstrated by different degrees of swallowing discomfort and obstructed breathing.Ultrasound examination revealed huge thyroid with abnormal shape and hard gland.Cytological examination found no malignant change.Eight patients received thyrotropin suppression therapy resulting in no effect.Four patients underwent surgery,in which 3patients recurred in 5to 6years.Five patients had finished the treatment by 131 I twice.After treatment,the serum thyroglobulin levels,thyroid mass,and radioactive iodine uptake rate reduced significantly,with the cure rate of 100%.Conclusion FG is clinically demonstrated by swallowing discomfort and obstructed breathing and 131 I is effective for it.
出处
《中华实用诊断与治疗杂志》
2015年第6期571-573,576,共4页
Journal of Chinese Practical Diagnosis and Therapy
作者简介
通信作者：刘国强，E—mail：1gq541223@163．com。
