摘要
目的探讨地屈孕酮与黄体酮联合人绒毛膜促性腺激素(HCG)治疗先兆流产的临床疗效。方法将80例先兆流产患者采用随机数字表法分为研究组和对照组,每组40例。对照组患者给予黄体酮联合HCG治疗,研究组患者给予地屈孕酮联合HCG治疗。比较两组患者保胎成功率、临床症状消失时间、激素水平变化和不良反应发生率。结果研究组患者保胎成功率明显高于对照组,且止血时间和腰腹痛缓解时间均明显短于对照组,差异均有统计学意义(均P<0.05);两组患者治疗后孕激素和HCG水平均明显升高,但两组组间比较差异无统计学意义(P>0.05),研究组患者孕激素和HCG水平恢复时间均明显短于对照组,差异有统计学意义(P<0.01);研究组患者不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论地屈孕酮联合HCG治疗先兆流产起效更快,疗效更佳。
Objective To study the clinical effects of dydrogesterone or progesterone combined with human chorionic gonadotropin（HCG）on threatened abortion.Methods A total of 80 patients with threatened abortion were randomly divided into study group and control group.The pregnancy outcomes, clinical symptoms relief time,change of hormone level and adverse reaction were compared between two groups.Results Patients in the study group, the success rate was significantly higher than the control group,and the bleeding time and lumbar pain relief time were significantly shorter than the control group,the differences were statistically significant（P〈0.05）;two groups of patients after treatment with progesterone and HCG levels were significantly increased, but there was no significant difference between the two groups（P〉0.05）,progesterone and HCG levels in patients with recovery time were significantly shorter than the control group, the difference was statistically significant（P〈0.01）;research incidence of adverse reactions in patients compared with the control group,the difference was not statistically significant（P〉0.05）. Conclusion Dydrogesterone combined with HCG has a better clinical effects on threatened abortion makes it worth for clinical application.
出处
《中国药物经济学》
2015年第6期45-47,共3页
China Journal of Pharmaceutical Economics
基金
2014年度佛山市医学类科技攻关项目(2014AB001134)
作者简介
王富海（1978-），本科学历。主管药师。研究方向：药学
