摘要
目的：探讨冠状动脉慢血流现象的相关影响因素。方法选取本院2011年1月~2013年6月冠状动脉造影显示心外膜主要冠状动脉无明显病变的200例患者作为研究对象，将校正的TIMI帧数大于正常冠状动脉血流速度2个标准差者定义为冠状动脉慢血流，分析冠状动脉慢血流组和冠状动脉正常组的年龄、性别、吸烟史、体重指数（BMI）、合并症（包括高血压、糖尿病和高脂血症）、以及血尿酸水平、同型半胱氨酸浓度、C反应蛋白水平、血小板聚集率等的差异，同时进一步通过多元回归分析观察上述因素中冠状动脉慢血流的危险因素。结果冠状动脉慢血流组的BMI、吸烟史的比例显著高于冠状动脉正常组，差异有统计学意义（P〈0.05）。冠状动脉慢血流组的血尿酸、同型半胱氨酸、C反应蛋白水平和血小板聚集率显著高于冠状动脉正常组，差异有统计学意义（P〈0.05）。多元回归分析结果显示，年龄、吸烟、高脂血症、血尿酸、同型半胱氨酸、C反应蛋白、血小板聚集率均是冠状动脉慢血流的危险因素。结论高龄、吸烟、高脂代谢状态和炎症状态以及高血小板聚集是促进冠状动脉慢血流发生的危险因素。
Objective To explore the risk factor of slow coronary flow （SCF） phenomenon. Methods 200 cases without obvious pathological changes of epicardial coronary artery by coronary angiography from January 2011 to June 2013 in our hospital were selected as the research object,the adjusted TIMI frame was more than 2 standard deviation of normal coronary flow velocity were defined as SCF.The comparison of age,gender,smoking history,body mass index（BMI）,comor-bidities（including hypertension,diabetes,and hyperlipidemia）,the level of and serum uric acid,C-reactive protein,platelet aggregation were analysed between the SCF group and the coronary artery normal group.The risk factor of SCF was analysed and observed by multiple regression analysis. Results BMI,the proportion of smoking history in the SCF group was higher than that in the coronary artery normal group,with significant difference （P〈0.05）.The level of serum uric acid,homocysteine,C reactive protein and platelet aggregation rate in the SCF group was higher than that in the normal group,with significant difference（P〈0.05）.Multivariate regression analysis showed that age,smoking,hyperlipidemia,serum uric acid,homocysteine,C reactive protein,platelet aggregation rate were the risk factors of SCF. Conclusion Age,smok-ing,high fat metabolism and inflammation status and high platelet aggregation are all risk factors of SCF phenomenon.
出处
《中国当代医药》
2015年第16期53-55,共3页
China Modern Medicine
作者简介
陈晖（1973-），女，广东省兴宁市人，本科，学士，副主任医师，研究方向：心血管疾病的内科I临床诊治与冠脉介入诊疗
