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保定地区新生儿先天性甲状腺功能低下症治疗及评估 被引量:3

Treatment and assessment of neonates with CH in baoding
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摘要 目的探讨保定地区筛查确诊的甲低患儿口服左旋甲状腺素钠(L-T4)的治疗效果。方法选取2008年-2012年在保定市新筛中心筛查确诊的甲低患儿为研究对象,口服左旋甲状腺素钠(L-T4),个体化治疗方案,定期复查甲功。并设患儿组为实验组,相匹配的正常儿童为对照组,采用spss13.0软件进行t检验和χ2检验,P≤0.05,为差异有统计学意义。比较两组身高、体重及智商的差别。结果患儿组的身高、体重和智商发育均接近于对照组,P>0.05,差异无统计学意义。结论经筛查确诊的CH患儿,通过尽早正规治疗,其体格及智商发育基本上接近正常同龄儿童。 Objective: This article discusses the effect of L-T4 treatment on Neonates with CH in Baoding. Methods: The objects of the research are the neonates confirmed as CH at the screening center of Banding during 2008-2012 that are under individualized L-T4 treatment and regular reexamination. The items such as height, weight and IQ are compared through statistics means between the experimental and control groups. Results: The difference in height, weight and IQ between the experimental and control groups, P〉0.05, has no statistical meaning. Conclusion: The physique and IQ of CH Neonates under early and professional treatment are close to normal children.
出处 《中国优生与遗传杂志》 2015年第5期78-79,90,共3页 Chinese Journal of Birth Health & Heredity
关键词 CH 左旋甲状腺素钠 治疗 CH L-T4 Treatment
作者简介 通讯作者:殷会芳
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参考文献11

  • 1中华人民共和国卫生部.新生儿疾病筛查技术规范[M].(2010版).2011-11-10.
  • 2无.先天性甲状腺功能减低症诊疗共识[J].中华儿科杂志,2011,49(6):421-424. 被引量:261
  • 3黄鸿眉,余加林.美国儿科学会最新先天性甲状腺功能低下新生儿筛查和治疗标准[J].实用儿科临床杂志,2010,25(2):155-156. 被引量:19
  • 4Beate O, Kjetil S' Bengt FK, et al.Congenital hypothyroidism : influence of disease severity and L-thyroxine treatment on intellectual, motor, and school-associated outcomes in young adults[J]. Pediatrics,2003, 112 (4) :923-930.
  • 5Adachi M, Askura Y. Final height and pubertal growth in Japanese patients with congenital hypothyroidism detected by neonatal screening[J]. ActaPaediatr,2003,92 (6) :698-703.
  • 6Malgorzata W, Filippo DL, Alessandra C, et al. In congenital hypothyroidism bone maturation at birth may be a predictive factor of psychomotor development during the first year of life irrespective of other variables related to treatment[J].Eur J Endocrinol, 2003, 149 (1) 11-6.
  • 7Leger J, Larroque B, Norton J. Influence of severity of congenitalhypothyroidism and adequacy of treatment on school achievement in young adolescents ..a population-based cohort study[J].Acta Paediatr, 2001,90 ( 11 ) : 1249-1256.
  • 8Hindmarsh PC. Optimisation of thyroxine dose in congenital hypothyroidism [J].Arch Dis Child, 2002, 86 ( 2 ) :73-75.
  • 9张爱平,黎剑,梁旭红,肖刚,曾菊华,张德红,向丽玲,胡金梅.怀化市新生儿先天性甲低的筛查与治疗评估[J].实用预防医学,2012,19(10):1474-1477. 被引量:11
  • 10苑丽双.128例新生儿先天性甲状腺功能低下症治疗观察[J].中国优生与遗传杂志,2013,21(2):92-92. 被引量:10

二级参考文献41

  • 1朱文斌,王振南,陈涵强,王旌,赵红,林枫,张红华.福建省九地市先天性甲状腺功能低下症新生儿筛查4年分析[J].中国优生与遗传杂志,2004,12(5):97-98. 被引量:22
  • 2杨茹莱,毛华庆,曹莉佩,周雪莲,陈肖肖,赵正言.浙江省新生儿先天性甲状腺功能减退症与苯丙酮尿症的筛查分析[J].中华预防医学杂志,2005,39(6):436-437. 被引量:51
  • 3陈肖肖,毛华庆,梁黎,曹莉佩,施玉华,周雪莲,曲一平,王旭,赵正言.新生儿先天性甲状腺功能低下症的筛查与治疗评估[J].实用儿科临床杂志,2006,21(2):73-75. 被引量:19
  • 4Rose SR, Brown RS, Foley T, et al. Update of newborn screening and therapy for congenital hypothyroidism [ J ]. Pediatrics, 2006, 117 ( 6 ) : 2290 - 2303.
  • 5Gu XF,Wang ZG,Ye J,et al.Newborn screening in China:phenylketonuria,congenital hypothyroidism and expanded neonatal screening.Ann Acad Med Singapore,2008,37(Suppl)12:107-110.
  • 6中华人民共和国卫生部.新生儿疾病筛查技术规范(2010版).,2011-11-10..
  • 7Grnters A,Biebermann H,Krnde H.Neonatal thyroid disorders.Horm Res,2003,59(Suppl 1):24-29.
  • 8Brown RS,Demmer LA.The etiology of thyroid dysgenesis still an enigma after all these years.J Clin Endocrinol Metab,2002,87:4069-4071.
  • 9Knobel M,Medeims-Neto G.An outline of inherited disorders of the thyroid hormone generating system.Thyroid,2003,13:771-801.
  • 10Kopp P.Perspective:genetic defects in the etiology of congenital hypothyroidism.Endocrinology,2002,143:2019-2024.

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