摘要
目的探讨慢性乙型肝炎患者医院病原菌感染的临床特点及病原学分析,为临床预防医院感染提供有利依据。方法选取2010年12月-2013年12月慢性乙型肝炎患者240例,依据不同年龄段进行分组,对比其感染率,通过菌株培养及鉴定判断引起感染的病原菌分布,分析感染的临床特点,明确慢性乙型肝炎患者易感染部位。结果 240例慢性乙型肝炎患者发生医院感染73例、84例次,感染率30.42%、例次感染率35.00%;73例感染患者中52例为多重感染,共分离出病原菌131株,其中革兰阴性菌占33.59%、革兰阳性菌占14.50%、真菌占51.91%;医院感染部位主要以腹腔为主占38.10%,其次为下呼吸道占15.48%;引起52例患者病原菌感染的因素主要为抗菌药物的滥用。结论感染是慢性乙型肝炎患者最多见的并发症之一,也是肝衰竭最终导致多脏器功能衰竭的始动原因,因此临床要加强慢性乙型肝炎患者医院感染相关危险因素的控制,依据病原学分析合理应用抗菌药物,积极预防与治疗感染是提高重型肝炎存活率的重要环节。
OBJECTIVE To investigate the clinical characteristics and etiology of nosocomial pathogenic infections in patients with chronic hepatitis B ,so as to provide a favorable basis for clinical prevention of nosocomial infections . METHODS Totally 240 patients with chronic hepatitis B during Dec .2010 to Dec .2013 were enrolled and divided into groups by age to compare the infection rate .Distribution of pathogens for infections was determined through strain culture and identification to analyze the clinical characteristics of infections and clarify the sites that were likely to be infected in patients with chronic hepatitis B .RESULTS There were 73 cases and 84 case‐times of nosocomial infections in the 240 patients with the infection rate of 30 .42% and the case‐time infection rate of 35 .00% .There were 52 cases of multiple infections in the 73 infected patients ,from whom 131 pathogens were isolated including gram‐negative bacteria ,gram‐positive bacteria and fungi accounting for 33 .59% ,14 .50% and 51 .91% .The main infection site was abdominal cavity accounting for 38 .10% ,followed by lower respiratory tract accounting for 15 .48% .The main cause for pathogenic infections in the 52 patients was abuse of antibiotics . CONCLUSION Infection is one of the most common complications of chronic hepatitis B ,and also the initiating cause of liver failure resulting in multiple organ failure .Therefore clinicians should strengthen the control of clini‐cal risk factors for nosocomial infections in patients with chronic hepatitis B and rationally use antibiotics based on etiological analysis .Active prevention and treatment is an important part of survival of severe hepatitis .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第12期2712-2714,共3页
Chinese Journal of Nosocomiology
基金
江西省卫生厅规划基金资助项目(JW-2011B030)
关键词
慢性乙型肝炎
医院感染
病原菌
危险因素
Chronic hepatitis B
Nosocomial infection
Pathogens
Risk factors
