摘要
目的:掌握市场上枳壳的销售、流通和质量情况,为制订新的枳壳质量标准及规范枳壳市场秩序提供参考。方法:运用实地抽样调查的方法,对浙江省内的零售药店及医疗机构的药房进行枳壳的专项检查,按照《中国药典》(2010年版)标准,从性状、薄层色谱法(TLC)鉴别和高效液相色谱法(HPLC)含量测定等角度进行分析,并记录药材的原产地及品种来源。结果:在抽查的40批枳壳样品中,有7批性状检查不合格,占总抽样数的17.50%;15批TLC鉴别不合格,占37.50%;15批HPLC含量测定不合格,占37.50%;TLC鉴别与HPLC含量测定存在相关性。40批样品中有32批来源符合《中国药典》规定,1批来源于地方习用品种常山胡柚,另外7批来源于橘类。40批枳壳样品中有16批产自江西、10批产自浙江、12批产自安徽、1批产自湖南,这4个产地均是枳壳的主产地;还有1批产自湖北。结论:枳壳药材中所含的成分受品种、产地、采收时间等影响。目前,枳壳终端市场上枳壳品种混乱、质量参差不齐,市售枳壳的监管力度有待加强,以保障消费者的用药安全、有效。
OBJECTIVE： To know the sales, circulation and quality of fructus aurantii in the market and provide references for the formulation of new quality standards for fructus aurantii and the standardization of the order of fructus aurantii market. METH- ODS： Special inspection over the fructus aurantii in the form of field sampling survey was conducted in the retail pharmacies and the pharmacies of medical institutions in Zhejiang province. According to Chinese Pharmacopoeia （2010 edition）, analysis was made on the basis of properties, identification by thin layer chromatography （TLC）, content determination by HPLC, etc.. The raw materials, places of origin and variety origins of the crude drugs were recorded. RESULTS： Among 40 batches of inspected samples, 7 were unacceptable in the inspection, accounting for 17.50% of total samples; 15 identified by TLC as unacceptable, ac- counting for 37.50% ; and 15 determined by HPLC as unacceptable, accounting for 37.50%. Furthermore, TLC identification was found to be correlated with HPLC content determination. Among the 40 batches of samples, the variety origins of 32 batches con- formed to the stipulations of Chinese Pharmacopoeia; 1 batch originated from Citrus changshan-huyou, a local conventional vari- ety; and 7 batches from the orange. 16 batches were produced in Jiangxi, 10 in Zhejiang, 12 in Anhui, and 1 in Hunan; such four provinces were the main places of origin of fructus aurantii. And the remaining 1 batch was produced in Hubei. CONCLUSIONS ： The components of fructus aurantii are influenced by the variety, place of origin and harvest time. Currently, the varieties of fruc- tus aurantii in the terminal market are multifarious, and the qualities are varying, thus it is necessary to tighten supervision over the sales of fructus aurantii so as to guarantee safety and effective use of drugs for consumers.
出处
《中国药房》
CAS
北大核心
2015年第16期2276-2278,共3页
China Pharmacy
基金
浙江省食品药品监督管理局科技专项(No.2014006)
浙江省衢州市科技计划项目(No.2014J018
2014Y021)
衢州职业技术学院重点科研项目(No.QZYZ1406)
关键词
市场调查
枳壳
检验
问题
建议
Market research
Fructus aurantii
Inspection
Problems
Suggestion
作者简介
副主任药师。研究方向：中药检验与质量评价。电话：0570-8358021。E-mail：sjfqz@163．com
通信作者：讲师，硕士。研究方向：中药分析与药效物质基础研究。电话：0570-8068339。E-mail：fengjingqian@126．com
