摘要
目的比较血清GP73和AFP检测对肝细胞癌(HCC)诊断的临床应用价值。方法用化学发光免疫分析法测定63例HCC、56例肝硬化、60例慢性肝炎和68健康对照血清AFP水平,ELISA法测定血清GP73水平。结果 HCC患者血清GP73和AFP水平与肝硬化、慢性肝炎和健康人群间的差异有统计学意义(P<0.05)。血清GP73对HCC的灵敏度(SEN)、特异性(SPE)和准确度分别为73.0%、89.7%和85.4%。血清AFP对HCC的SEN、SPE和准确度分别为57.1%、88.0%和80.2%。血清GP73+AFP并联试验对HCC的SEN、SPE和准确度分别为81.0%、81.0%和81.0%。GP73和AFP的ROC曲线下面积分别为0.889和0.796。结论血清GP73对肝细胞癌的诊断效能优于血清AFP,GP73是HCC诊断的较好血清标志物。
Objective To compare the clinical values of serum golgi protein 73 （GP73） and alpha-fetoprotein （AFP） for diagnosis of hepatocellular cancer （ HCC ）. Methods The levels of serum GP73 and AFP were measured in 63 patients with HCC,56 patients with liver cirrhosis,60 patients with chronic hepatitis and 68 healthy persons. Results The levels of GP73 and AFP were significantly higher in patients with HCC than those in patients with liver cirrhosis, chronic hepatitis and healthy persons （P 〈 0.05 ）. The diagnosis sensitivity, specificity and accuracy of GP73 were 73.0%, 89.7% and 85.4% , respectively. The di- agnosis sensitivity, specificity and accuracy of AFP were 57.1% ,88.0% and 80. 2% , respectively. The diagnosis sensitivity, specificity and accuracy of GP73/AFP parallel detection were 81.0%, 81.0% and 81.0% , respectively. Areas under the ROC curves of GP73 and AFP were 0. 889 and 0. 796, respectively. Conclusion The efficiency of GP73 in diagnosis of HCC was bet- ter than AFP. GP73 was a better serological marker in diagnosis of HCC.
出处
《四川医学》
CAS
2015年第5期716-718,共3页
Sichuan Medical Journal
关键词
肝细胞癌
高尔基体蛋白73
甲胎蛋白
诊断
hepatocellular cancer
golgi protein 73
alpha-fetoprotein
diagnostic
