摘要
目的：探讨氧化低密度脂蛋白（ox－LDL）、C 反应蛋白（CRP）对经皮冠状动脉介入治疗（PCI）术后支架内再狭窄（ISR）的预测价值。方法选择行 PCI 术并于术后6个月内接受冠状动脉造影复查的患者186例，其中术后发生 ISR （ISR 组）22例，无 ISR 发生（非 ISR 组）164例。检测两组 PCI 术前和术后血清 ox－LDL、CRP水平。结果 ISR 组和非 ISR 组年龄、性别构成、合并症、血脂水平、血管病变情况等一般资料差异均无统计学意义（P ＞0．05）。 ISR 组 PCI 术后 ox－LDL、CRP 水平明显高于术前（P ＜0．05），而非 ISR 组 PCI 术前和术后ox－LDL、CRP 水平无明显改变（P ＞0．05）。 ISR 组术前、术后 ox－LDL 水平均高于非 ISR 组（P ＜0．05）；术前2组CRP 水平差异无统计学意义（P ＞0．05），术后 ISR 组明显高于非 ISR 组（P ＜0．05）。相关分析显示 ISR 组、非ISR 组无论是 PCI 术前还是 PCI 术后，ox－LDL 与 CRP 均呈正相关[ISR 组：术前、术后 r 值（P 值）分别为0．392（0．020）、0．431（0．010）；非 ISR 组：术前、术后 r 值（P 值）分别为0．382（0．024）、0．526（0．001）]；Logistic回归分析显示术后 ox－LDL[优势比（OR）＝1．27，95％可信区间（CI）：1．05～1．79]和术前 CRP 水平（OR ＝1．82，95％CI：1．68～2．30）是 ISR 的独立危险因子。结论 PCI 术后 ox－LDL 和术前 CRP 水平升高对预测 ISR 发生有一定的临床价值。
Objective To investigate the predictive significance of oxidized low-density lipoproteins （ox-LDL） and C reactive protein （CRP） for in-stent restenosis （ISR） after percutaneous coronary intervention （PCI）. Methods A total of 186 patients who were given PCI and followed up for 6 months were enrolled.Of them, 22 patients had ISR（ISR group）, while the other 164 patients had not ISR（no-ISR group）.The pre-and post-PCI serum ox-LDL and CRP were detected.Results There was no statistical significance between the 2 groups in terms of age, sex, morbidity, serum lipid and vessel lesion（P 〉0.05）.Serum ox-LDL and CRP increased significantly in ISR group at post-PCI compared with pre-PCI （P 〈0.05）, while there was no significant change in no-ISR group （P〉0.05）.Serum ox-LDL were also higher in ISR group compared with no-ISR group at pre-and post-PCI （P 〈0.05）.There was no statistical significance for CRP level between the 2 groups at pre-PCI （P ＆gt;0.05）.However, the significant increase of CRP level in ISR group compared with no-ISR group was present at post-PCI （P 〈0.05）.Correlation analysis revealed that there was positive correlation between pre-and post-PCI for serum ox-LDL and CRP in both ISR and no-ISR groups [ISR group： r（P） values of pre-and post-PCI were 0.392 （0.020） and 0.431 （0.010）; no-ISR group： r（P） values of pre-and post-PCI were 0.382 （0.024） and 0.526 （0.001）].The Logistic regression analysis showed that post-PCI ox-LDL [odds ratio （OR） =1.27, 95% confidence interval （CI）： 1.05-1.79] and pre-PCI CRP （OR =1.82,95%CI：1.68-2.30） were independent risk factors of ISR.Conclusions Post-PCI ox-LDL and pre-PCI CRP have certain significance in the prediction of ISR.
出处
《检验医学》
CAS
2015年第5期484-488,共5页
Laboratory Medicine
基金
广西医药卫生科学研究基金资助项目(Z2012636)
关键词
氧化低密度脂蛋白
C
反应蛋白
经皮冠状动脉介入
再狭窄
Oxidized low-density lipoprotein
C reactive protein
Percutaneous coronary intervention
In-stent restenosis
作者简介
作者简介：何文军，男，1972年生，学士，主任技师，主要从事临床免疫学检验工作。
