摘要
目的：通过临床试验,观察螺旋CT引导下氩氦靶向治疗恶性实体肿瘤的疗效及其影响因素,为恶性实体肿瘤患者的临床治疗方案选择提供依据。方法：选择150例恶性实体肿瘤患者,在螺旋CT引导下进行氩氦刀冷冻消融治疗,分析瘤体冰球覆盖率,并在术后随访监测,记录疗效及并发症。结果：150例患者共有瘤体265个,瘤体直径范围为1.2-12 cm,中位数为4.21 cm。与直径〉3 cm的瘤体比较,瘤体≤3 cm的冰球覆盖率较好（P〈0.05）。术后1、3、6、12个月的肿瘤消融治疗有效率分别为81.13%、71.76%、71.07%、68.10%,肿瘤控制率分别为96.23%、91.37%、85.54%、80.95%;肿瘤直径和肿瘤分期是术后1年疗效的影响因素（P〈0.05）。结论：螺旋CT引导下氩氦靶向治疗恶性实体肿瘤的效果较好,可以在临床上应用。
Objective： To observe the clinical effect of spiral CT guidance argon-helium cryablation on malignant solid tumors and the influencing factors of the treatment effects. Methods： 150 patients of malignant solid tumors were selected who were confirmed by pathology. After the cryablation therapy, follow-up were carried out and the treatment effect and the related complications were recorded. Results： There were 265 tumors in the 150 patients. The diameter of tumors ranged from 1.2 cm to 12 cm, with a median of 4. 21cm. Compared with the ice coverage of tumors larger than 3 cm in diameter, ice coverage of tumors less than 3 cm was better（P 〈 0. 05 ）. The efficient rates were 81.13%, 71.76%,71.07% and 68. 10% in 1,3,6,12 months respectively, and the controlling rates were 96. 23%,91.37%,85.54% and 80.95%, respectively. Tumor diameter and tumor staging were the influence factors of curative effect in one year after therapy （ P 〈 0. 05 ）. Conclusion： Spiral CT guidance argonhelium cryablation was good for the treatment of malignant solid tumors, which could be used in clinics.
出处
《现代医学》
2015年第4期420-423,共4页
Modern Medical Journal
关键词
氩氦刀
恶性实体肿瘤
螺旋CT
疗效
argon- helium knife
malignant solid tumors
spiral CT
effect
作者简介
沈立杰（1978-），男，河北邢台人，主治医师，医学硕士。E—mall：iwish_2002@163．com
