摘要
目的评价低剂量阿司匹林(LDA)在预防高危孕妇子痫前期(PE)的作用及疗效。方法采用随机、对照、双盲实验将480名12周及20周孕妇分为12个组别,分别给予50mg/d、100mg/d及150mg/d剂量的LAD和安慰剂,比较各组间的子痫发生情况、分娩孕周、孕妇产后出血量、早产及胎儿生长受限、新生儿出血性疾病发生、新生儿死亡率等情况。观察合适的服用LDA的时间和剂量。结果 12周与20周孕妇不同剂量LDA组结果均显示,服用LDA的子痫发生率均低于服用安慰剂组,而且以100mg/d组别子痫发生率最低,差异具有统计学意义(x^2=29.838,P<0.05);12周结果显示早产发生、新生儿出血性疾病发生情况方面,服用LDA与服用安慰剂均无统计学差异(x^2值分别为1.441、1.034,均P>0.05);但是服用LDA组发生胎儿生长受限及新生儿死亡情况显著低于服用安慰剂组,且差异有统计学意义(x^2值分别为13.317、15.984,均P<0.05)。20周结果显示在早产发生、胎儿生长受限、新生儿出血性疾病发生情况方面,服用LDA与服用安慰剂并无统计学差异(x^2值分别为1.441、6.117、0.835,均P>0.05);但是服用LDA组发生新生儿死亡情况显著低于服用安慰剂组,且差异有统计学意义(x^2=15.984,P<0.05);12孕周服用LDA各组较20孕周服用LDA各组的子痫发生率低显著降低(x^2=11.663,P<0.05)。结论 12周服用LDA100mg/d可以有效降低PE的发生,具有预防效果。
Objective To evaluate the effectiveness of low-dose aspirin （LDA） on preventing preeclampsia （PE） in high-risk pregnant women.Methods A total of 480 women at 12 and 20 weeks of gestation were divided into 12 groups in a randomized, controlled and double-blind study, and they were given 50mg/d, 100mg/d, 150mg/d dose of aspirin and placebo.The incidence of eclampsia, gestational weeks, amount of postpartum hemorrhage, premature birth and fetal growth restriction, neonatal hemorrhagic disease and neonatal mortality rate were compared among each groups.The right time and dose of taking LDA were observed.Results The incidence of eclampsia in groups taking LDA was significantly lower than that of the groups taking placebo,and it was lowest in the group taking 100mg/d of aspirin （χ^2 =29.838, P〈0.05）.In pregnant women at 12 gestational week, there was no significant difference in the occurrence of premature delivery and neonatal hemorrhagic disease between groups taking LDA and those taking placebo （χ^2 value was 1.441 and 1.034, respectively, both P〉0.05） , but the occurrence of fetal growth restriction and neonatal death in groups taking LDA was significantly lower than that of the groups taking placebo （χ^2 value was 13.317 and 15.984, respectively, both P 〈0.05）.In pregnant women at 20 gestational week, the groups taking LDA were not significantly different from those taking placebo in the occurrence of premature delivery, fetal growth restriction and neonatal hemorrhagic disease （χ^2 value was 1.441, 6.117 and 0.835, respectively, all P〉0.05）, but the incidence of neonatal death in groups taking LDA was significantly lower than that of the groups taking placebo （χ^2 =15.984,P〈0.05）. The incidence of eclampsia in women taking LDA at 12 weeks of gestation was significantly lower than that of the women taking LDA at 20 weeks of gestation （χ^2 =11.663, P〈0.05）.Conclusion Women at 12 weeks of gestation taking 100mg/d of LDA can effectively reduce the incidence of PE.
出处
《中国妇幼健康研究》
2015年第2期295-297,共3页
Chinese Journal of Woman and Child Health Research
关键词
低剂量
阿司匹林
子痫前期
预防
low dose
aspirin
preeclampsia （PE）
prevention
作者简介
朱云花（1977-），女，副主任医师，主要从事妊娠期高血压疾病、产科危重症诊疗工作。
