摘要
目的：探讨不同浓度七氟烷联合丙泊酚对小儿麻醉后肌钙蛋白I、C反应蛋白以及补体变化的影响。方法：选取ASAⅠ-Ⅱ级择期行非心脏手术患者96例,随机分为三组,其中A组32例给予2%七氟烷联合丙泊酚麻醉;B组32例给予2.5%七氟烷联合丙泊酚麻醉;C组32例给予3%七氟烷联合丙泊酚麻醉。分别于全身麻醉诱导前（T1）、麻醉开始后30min（T2）、手术结束后3h（T3）3个时间点检测三组患者血清肌钙蛋白I（cTn I）、C反应蛋白（CRP）和补体（C3、C4）含量水平。结果：1三组在麻醉前cTn I、CRP、C3、C4均无明显差异（P〉0.05）;2与T1相比较,三组在T2、T3时cTn I、CRP、C3、C4均明显升高（P〈0.05）;3相同时间各组间对比,B、C两组在T2、T3时cTnI、CRP、C3、C4明显高于A组（P〈0.05）;C组在T2、T3时cTnI、CRP、C3、C4较B组明显升高（P〈0.05）。结论：七氟烷在有效浓度范围内与患者心肌损害成正相关,低浓度的七氟烷联合丙泊酚适合于小儿手术时全身麻醉诱导。
Objective ：To explore the different concentration of sevoflurane combined propofol for pediat‐ric anesthesia after troponin I ,changes of c‐reactive protein and complement .Methods ：Selection of ASA Ⅰ - Ⅱlevel marked line 96 cases of patients without heart surgery ,were randomly divided into three groups ,including A group of 32 cases ,to 2% sevoflurane combined propofol anesthesia ;B group of 32 cases ,to 2 .5% sevoflurane com‐bined propofol anesthesia ;32 cases of group C ,grant 3% sevoflurane combined propofol anesthesia .Respectively with systemic narcotic induction before anesthesia （T1 ） ,30 minutes after the start （T2 ） ,after 3 hours （T3 ） detection of three time points ,three groups of patients serum troponin I （cTn I） ,c‐reactive protein （CRP） and comple‐ment （C3 and C4 ） levels .Results ： ① Three sets of cTn I before anesthesia ,CRP ,C3 and C4 were no obvious differ‐ence ,there was no statistical significance （P〉 0 .05） ;② Compared with T1 ,three groups in T2 ,T3 cTn I ,CRP ,C3 and C4 were significantly increased ,the difference was statistically significant （P 〈 0 .05） ; ③ The same time each group contrast ,B and C in the two groups in T2 ,T3 cTnI ,CRP ,C3 and C4 were significantly higher than those in group A ,the difference was statistically significant （P〈 0 .05） ;Group C cTnI in T2 ,T3 ,CRP ,C3 and C4 increased significantly in the B group ,the difference was statistically significant （P 〈 0 .05） .Conclusion ：Sevoflurane in ef‐fective concentration range ,higher concentration of patients with myocardial damage into positive correlation ,the higher the concentration of children perioperative stress response is sensitive , prompted to low concentration of sevoflurane combined propofol for without induction of general anesthesia surgery ,to give a guidance of clinical , worth clinical promotion .
出处
《陕西医学杂志》
CAS
2015年第5期541-543,共3页
Shaanxi Medical Journal
基金
浙江省医药卫生一般研究计划项目(2012KYA141)
作者简介
通讯作者
