摘要
目的:探讨不同手术方式、组织学分型及肿瘤分期对分化型甲状腺肿瘤患者预后的影响。方法:回顾性分析1994年7月-2005年7月分化型甲状腺癌患者125例,中位随访时间为9年。采用Kaplan-M eier生存分析和COX多因素回归模型分析颈部淋巴结清除、甲状腺切除、病理学类型和癌症分期等临床因素与无病生存率及总生存率的关系。结果:经过平均99.7个月的随访,无病生存率为77.5%,总生存率为93.6%。癌症分期与病患的无病生存率成反比(P=0.025);滤泡状肿瘤的无病生存率和总生存率均低于乳头状肿瘤的无病生存率(P<0.05),而颈部淋巴结清扫与否以及是否切除甲状腺对预后的影响差异无统计学差异(P>0.05)。结论:肿瘤分期与组织学分型是分化型甲状腺癌预后的主要影响因素。
bjective： To analyze effects of different surgical treatments, pathological types and cancer stage on prognosis in patients with differentiated thyroid cancer. Methods： 125 patients treated for differentiated thyroid cancer treated in our hospital between July 1994 and July 2005 were analyzed retrospectively in this study. The relationships between cervical lymph node removal,thyroid gland resection, pathology type and cancer stage and overall survival were evaluated by Kaplan-M eier survival analysis and Cox multi-factor regression model. Results： W ith a median follow-up of 99.7 months the entire set of cases of disease-free survival rate（DFS）was 77.5%; the over allsurvivalrate（OS） was 93.6%. Cancer staging is inversely proportionalto the DFS of patients（P=0.025）. DFS（P〈0.05）and OS（P〈0.05）of follicular neoplasmwere lower than papillary tumor,neck lymph node cleaning and removal had no significant impact on the outcome（P〈0.05）. Conclusion： Cancer stage and tumor differentiation were significant prognostic factors for differentiated thyroid cancer.
出处
《中国现代普通外科进展》
CAS
2015年第3期182-184,188,共4页
Chinese Journal of Current Advances in General Surgery
关键词
分化型甲状腺癌
颈部淋巴结清除
甲状腺切除
病理学类型
癌症分期
预后
Differentiated thyroid carcinoma
Cervical lymph nodes
Total thyroidectomy
Tumordifferentiation
Cancer stage
Prognosis
作者简介
仲崇威（1966—11-），男，副主任医师，研究方向：甲状腺外科疾病的治疗。E—mail：zewei2@163．com
