摘要
目的:评价中药活血化瘀法治疗溃疡性结肠炎的临床疗效及安全性。方法:检索2014-06以前中国知网医学数据库(CNKI),维普全文数据库(VIP),中国生物医学文献数据库(CBM),万方数据库,搜集中药活血化瘀法治疗溃疡性结肠炎的随机对照试验。对符合条件的RCT,提取资料和质量评价后,采用Stata12.0软件进行Meta分析。结果:共有20项临床试验纳入1 897例患者。Meta分析结果显示:总有效率[RR=1.248,95%CI(1.187,1.313),Z=8.66,P<0.01];具有较好的安全性。敏感性分析显示结果比较稳定。漏斗图,Egger’s检验及Begg’s检验显示发表偏倚较小。结论:中药活血化瘀法治疗溃疡性结肠炎的临床疗效优于西药组并且安全性高。但纳入文献质量较低,因此尚需开展大规模、高质量的研究来验证。
Objective： The aim of this study was to evaluate the safety and efficacy of Huoxue Huayu method of Chinese herbal medicine in the treatment of ulcerative colitis （UC）. Method： All the randomized controlled trials （RCTs） on activating blood circulation to remove blood stasis method of Chinese herbal medicine in the treatment of UC before June 2014 were searched in the CNKI, VIP, CBM and Wangfang database. The quality of RCTs meeting inclusion criteria was assessed and the related data were extracted; Meta-analysis was performed by Statal2.0 software. Result： Totally, 20 RCTs involving 1 897 patients were included. Meta-analysis showed high effective rate [the total effective rate RR=1. 248, 95% CI （1. 187, 1. 313）, Z =8.66, P 〈0.01] and safety. Sensitivity analysis showed that the evaluation result was stable. Funnel plot, Egger＇s test and Begg＇s test suggested no evidence of substarltial publication bias. Conclusion： Huoxue Huayu method is more effective in the treatment of UC than the western medicine with higher safety. Because of the low quality of the included RCTs, the improvement of clinical research on the disease in high quality need to be confirmed.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2015年第10期220-224,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
安徽省科技厅年度重点科研项目(10050511070403042)
作者简介
[通讯作者]查安生，硕士，主任医师，教授，从事中医药防治脾胃病学研究，Tel：0551．62850082，E—mail：wywyhf@163．com.
