摘要
目的探讨老年心力衰竭急性发作期患者血钠(Na)、B型钠尿肽(BNP)和尿酸(UA)水平变化及其与心功能的关系。方法选取2011—2013年重庆市永荣矿业有限公司总医院收治的老年心力衰竭急性发作期患者60例作为疾病组,选择同期老年心力衰竭稳定期患者60例作为疾病对照组,另选择同期门诊体检健康者70例作为对照组。比较3组受试者血Na、BNP、UA水平,比较疾病组不同心功能分级患者血Na、BNP、UA水平变化,分析其与心功能分级的相关性。结果疾病组患者血BNP、UA水平高于疾病对照组,血Na水平低于疾病对照组(P<0.05);疾病对照组患者血BNP、UA水平高于对照组,血Na水平低于对照组(P<0.01)。疾病组患者中心功能分级Ⅳ级者血BNP、UA水平高于Ⅲ级者和Ⅱ级者,Ⅲ级者高于Ⅱ级者(P<0.05);Ⅳ级者血Na水平低于Ⅲ级者和Ⅱ级者,Ⅲ级者低于Ⅱ级者(P<0.05)。Pearson相关分析结果显示,老年心力衰竭急性发作期患者血Na水平与心功能分级呈负相关(r=-0.602,P=0.006),血BNP水平与心功能分级呈正相关(r=0.551,P=0.012),血UA水平与心功能分级呈正相关(r=0.498,P=0.021)。结论老年心力衰竭急性发作期患者血BNP、UA水平升高,血Na水平降低,且血Na、BNP、UA水平与患者心功能分级相关。
Objective To investigate the changes of serum levels of sodium,BNP and uric acid in aged patients with acute exacerbation of heart failure and their correlations with cardiac function. Methods From 2011 to 2013 in the General Hospital of Yongrong Mining Limited Company of Chongqing,60 aged patients with acute exacerbation of heart failure were selected as A group,60 aged patients with stable heart failure were selected as B group,70 aged healthy cases were selected as C group. Serum levels of sodium,BNP and uric acid were detected and compared,and their correlations with cardiac function were analyzed. Results Serum levels of BNP and uric acid of A group were higher than those of B group,while serum sodium level was lower than that of B group （ P 〈0. 05 ）;serum levels of BNP and uric acid of B group were higher than those of C group,while serum sodium level was lower than that of C group（P〈0. 05）. In A group,serum levels of BNP and uric acid of patients withⅣ-stage cardiac function were higher than patients withⅢ- andⅡ-stage cardiac function,and those of patients with Ⅲ-stage cardiac function were higher than patients withⅡ-stage cardiac function （ P〈0. 05 ）;serum sodium level of patients with Ⅳ-stage cardiac function was lower than patients with Ⅲ- andⅡ-stage cardiac function,and that of patients withⅢ-stage cardiac function was lower than patients withⅡ-stage cardiac function（P〈0. 05）. Pearson correlation analysis showed that,serum sodium level was negatively correlated with cardiac function of aged patients with acute exacerbation of heart failure（r= -0. 602,P=0. 006）,while serum BNP level（r=0. 551,P=0. 012）and serum uric acid level（r=0. 551,P=0. 012） was positively correlated with cardiac function,respectively. Conclusion Serum levels of BNP and uric acid of aged patients with acute exacerbation of heart failure are high,while the serum sodium level is low,but all of them are correlated with the cardiac function.
出处
《实用心脑肺血管病杂志》
2015年第3期6-8,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
心力衰竭
老年人
钠
利钠肽
脑
尿酸
心功能
Heart failure
Aged
Sodium
Natriuretic peptide, brain
Uric acid
Heart funcion
