摘要
胰岛素样生长因子1(IGF1),具有调节组织细胞增殖、分化、有丝分裂等功能。研究表明IGF1不仅参与众多疾病的发生,还参与了不同组织和器官的发育过程。对IGF1信号通路及其在机体发育中的作用进行了综述。
Insulin-like growth factor 1 (IGF1) is a multi-functional protein which plays the important roles in regulating cell proliferation, differentiation and mitosis. Studies have shown that IGF1 is not only involved in the occurrence of many diseases, but also participated in the development process of different tissues and organs. The IGF1 signaling pathway and its roles in the development of tissues and organs are reviewed.
出处
《生命科学研究》
CAS
CSCD
2015年第2期165-168,184,共5页
Life Science Research
基金
福建省教育厅重点项目(JA12061)
关键词
胰岛素样生长因子1
胰岛素样生长因子1受体
胰岛素样生长因子结合蛋白
信号通路
发育
insulin-like growth factor I(IGF1)
insulin-like growth factor 1 receptor (IGF1R)
insulin-likegrowth factor-binding protein (IGFBP)
signaling pathway
development
作者简介
曾永芬(1989-),女,福建龙岩人,硕士研究生,主要从事机体器官的发育与再生;
通讯作者:黄义德(1971-),男,福建松溪人,博士,副教授,主要从事分子信号通路研究,Tel:0591-22868193,E-mail:ydhuang@fjnu.edu.cn。