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盐酸右美托咪定辅助舒芬太尼在腹腔镜全子宫切除术后镇痛中的应用 被引量:8

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摘要 目的:观察盐酸右美托咪定辅助舒芬太尼应用于腹腔镜全子宫切除术后患者自控静脉镇痛(PCIA)的效果。方法40例择期全麻下行腹腔镜全子宫切除术患者,ASAⅠ-Ⅱ级。随机分为2组,每组20例,对照组PCIA 给予生理盐水+枸橼酸舒芬太尼0.04μg/(kg· h)+托烷司琼4 mg 至100 ml;实验组 PCIA 给予盐酸右美托咪定0.08μg/(kg·h)+枸橼酸舒芬太尼0.02μg/(kg·h)+托烷司琼4 mg 至100 ml。记录术后1、4、8、24、48 h 各时点镇痛视觉模拟评分(VAS),Ramsay 镇静评分及恶心、呕吐、眩晕、呼吸抑制及低氧血症等不良反应发生情况。结果术后各时点实验组患者 VAS 评分较对照组差异无统计学意义(P >0.05),实验组不良反应发生率较对照组低(P <0.05),Ramsay 镇静评分较对照组高(P <0.05)。结论右美托咪定作为一种术后辅助镇痛镇静药用于术后镇痛,能适度镇静,减少芬太尼类药物的用量,降低不良反应发生率。
出处 《徐州医学院学报》 CAS 2015年第3期191-192,共2页 Acta Academiae Medicinae Xuzhou
作者简介 通信作者,E—mail:qdy6808@sina.com
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参考文献5

  • 1Woolf CJ.Central sensitization:Implications for the diagnosis and treatment of pain[J].Pain,2011,152(3 Suppl):S2-SI5.
  • 2刘清仁,季永.右美托咪定镇痛作用的研究进展[J].国际麻醉学与复苏杂志,2014,35(3):276-279. 被引量:35
  • 3葛蕾,齐敦益.盐酸右美托咪定辅助舒芬太尼术后镇痛研究[J].徐州医学院学报,2012,32(12):790-793. 被引量:12
  • 4Ebert TJ,Hall JE,Bamey JA,et al.The effects of increasing plasma concentrations of dexmedetomidine in humans[J].Anes-thesiology,2000,93(2):382-394.
  • 5Hall JE,Uhrich TD,Bamey JA,et al.Sedative,amnestic,and analgesic properties of small-dose dexmedetomidine infusions[J].Anesth Analg,2000,90(3):699-705.

二级参考文献43

  • 1马加海,徐礼鲜,张国良,卢玲玲,徐瑞芬,李源,王惠霞.舒芬太尼、芬太尼用于颌面外科术后镇痛的对比观察[J].中国疼痛医学杂志,2005,11(3):154-156. 被引量:28
  • 2Kanazi GE, Aouad MT, Jabbour-Khoury SI, et al. Effect of low- dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block [J]. Acta Anaesthesiol Scand, 2006, 50 (2): 222-227.
  • 3Kuraishi Y, Hirota N, SatoY, et al. Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn[J ]. Brain Res, 1985, 359(1-2) : 177-182.
  • 4Poree LR, Guo TZ, Kingery WS, et al. The analgesic potency of dexmedetomidine is enhanced after nerve injury: a possible role for peripheral alpha2-adrenoceptors [J]. Anesth Analg, 1998, 87(4): 941-948.
  • 5Nelson LE, Lu J, Guo T, et al. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects [J]. Anesthesiology, 2003, 98 (2): 428-436.
  • 6A1-Metwalli RR, Mowafi HA, Ismail SA, et al. Effect of intra- articular dexmedetomidine on postoperative analgesia after arthroscopic knee surgery[J]. Br J Anaesth, 2008, 101(3): 395- 399.
  • 7Schmidt AP, Valinetti EA, Bandeira D, et aL Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children [J]. Paediatr Anaesth, 2007, 17(7): 667-674.
  • 8Wahlander S, Frumento R J, Wagener G, et al. A prospective, double -blind, randomized, placebo -controlled study of dexmedetomidine as an adjunct to epidural analgesia after thoracic surgery [ J ]. J Cardiothorac Vasc Anesth, 2005, 19 (5) : 630-635.
  • 9Toyama H, Wagatsuma T, Ejima Y, et al. Cesarean section and primary pulmonary hypertension: the role of intravenous dexmedetomidine [ J ]. Int J Obstet Anesth, 2009, 18 (3) : 262-267.
  • 10Ghali AM, Mahfouz AK, A1-Bahrani M. Preanesthetic medication in children:A comparison of intranasal Dexmedetomidine versus oral midazolam[J]. Saudi J Anaesth, 2011, 5(4): 387-391.

共引文献43

同被引文献87

  • 1Reardon DP,Anger KE,Adams CD,et al.Role of dexmedetomidine in adults in the intensive care unit:an update[J].Am J Health Syst Pharm,2013,70(9):767-77.
  • 2Eren G,Cukurova Z,Demir G,et al.Comparison of dexmedetomidine and three different doses of midazolam in preoperative sedation.Journal of Anaesthesiology Clinical Pharmacology[J].2011,27(3):367-32.
  • 3Apfelbaum JL,Chen C,Mehta SS,et al.Postoperative pain experience:results from a national survey suggest postoperative pain continues to be undermanaged[J].Anesth Analg,2003,97(2):534-40.
  • 4Al Samaraee A,Rhind G,Saleh U,et al.Factors contributing to poor post-operative abdominal pain management in adult patients:a review[J].Surgeon,2010,8(3):151-158.
  • 5Ericson L,Ambring A,Bjrholt I,et al.Opioid rotation in patients initiated on oxycodone or morphine:a register study[J].J Pain Res,2013,6:379-386.
  • 6Staahl C,Christrup LL,Andersen SD,et al.A comparative study of oxycodone and morphine in a multi-modal,tissue-differentiated experimental pain model[J].Pain,2006,123(1-2):28-36.
  • 7Zhang X,Bai X.New therapeutic uses for an alpha2 adrenergic receptor agonist--dexmedetomidine in pain management[J].Neurosci Lett,2014,561:7-12.
  • 8夏婧,张玮,钱传云.镇静治疗对ICU危重患者应激的预防作用[J].临床麻醉学杂志,2009,25(1):64-65. 被引量:29
  • 9吕磊,江时森.再灌注损伤挽救激酶信号通路在心肌再灌注损伤保护中的研究进展[J].医学研究生学报,2010,23(12):1309-1313. 被引量:10
  • 10林莹,陈彦青,戴双波.舒芬太尼复合右美托咪定妇科腔镜手术术后镇痛效果观察[J].临床麻醉学杂志,2011,27(7):690-692. 被引量:80

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