摘要
目的 探讨换血治疗的并发症及其对新生儿胆红素脑病患儿预后的影响.方法 将2009年1月1日至2014年12月31日在广东省妇幼保健院新生儿科住院入院诊断新生儿胆红素脑病的足月新生儿作为研究对象,记录患儿一般情况、胆红素峰值水平,以进行换血治疗的患儿为换血组、未进行换血治疗者为对照组,比较两组患儿并发症（贫血、窦性心动过缓、坏死性小肠结肠炎、败血症、电解质紊乱、血小板减少症）的发生率,比较两组患儿死亡、脑损害及听力损害情况.结果 6年间我院共收治入院时诊断胆红素脑病患儿42例;换血治疗26例（61.9％）,换血组患儿贫血、窦性心动过缓、电解质紊乱发生率明显高于对照组,但两组患儿血小板减少症、坏死性小肠结肠炎（NEC）、败血症的发生率差异无统计学意义;换血组患儿死亡率低于对照组,但差异无统计学意义;两组患儿脑损害、听力损害的发生率差异无统计学意义.结论 换血治疗能够快速降低胆红素脑病患儿血中胆红素水平及B/A值,但会增加该组患儿贫血、电解质紊乱、心动过缓等并发症的发生率;换血治疗不能降低已存在胆红素脑病患儿的脑损害、听力损害发生率.
Objective To investigate the effect of exchange-transfusion therapy on prognosis of infants with bilirubin encephalopathy and complications.Methods Full term infants diagnosed as bilirubin encephalopathy in neonatology department of our hospital from January 1,2009 to December 31,2014 were selected as research objective,recorded their general condition and peak value of bilirubin,infants undergoing exchange-transfusion therapy as exchange-transfusion group,others as control group,compared the incidences of complications,death,cerebral lesion and hearing lesion of two groups.Results There were 42 infants with bilirubin enephalopathy during 6 years,26 infants （61.9%） in whom underwent exchange-transfusion therapy.The incidences of anemia,sinus bradycardia,electrolyte disturbance in exchange-transfusion group were significantly higher than those in control group,but there were no statistically significant differences in the incidences of thrombopenia,necrotizing enterocolitis,septicemia,death,cerebral lesion and hearing lesion between two groups.Conclusions Exchange-transfusion therapy can rapidly decrease levels of bilirubin and B/A,but can increase the incidences of anemia,sinus bradycardia,electrolyte disturbance.Exchange-transfusion therapy cannot improve the prognosis of infants with bilirubin encephalopathy.
出处
《国际医药卫生导报》
2015年第10期1371-1373,1376,共4页
International Medicine and Health Guidance News
关键词
胆红素脑病
新生儿
换血治疗
预后
Bilirubin encephalopathy
Newborn
Exchange-transfusion
Prognosis
作者简介
通信作者：陈运彬，E-mail：yunbin_chen@hotmail.com
