摘要
生殖细胞中的表观遗传信息是由DNA和染色质修饰决定的,这些修饰在生殖细胞的发育过程中是动态变化的。表观遗传修饰因子及其调控蛋白,包括DNA甲基转移酶、组蛋白修饰酶、B淋巴细胞成熟诱导蛋白1(BLIMP1)、钙调蛋白依赖性蛋白激酶4(Camk4)等,在生殖细胞的发生和发育过程中对其细胞基因组的重编程、下游靶基因的激活和抑制以及生殖细胞特异性事件,如生殖细胞的发育、减数分裂的调控、染色体配对以及基因组的完整性等都有重要的作用。结合近年来对哺乳动物生殖细胞发生和发育与表观遗传学相关性的研究进展予以综述。
The epigenetic profile of germ cells is defined by the modifications of DNA and chromatin.Meanwhile,those modifications dynamically change during germ cell development. Epigenetic modifiers and their regulatory proteins,such as DNA methyltransferases,histone modification enzymes,B-lymphocyte maturation-induced protein 1（BLIMP1） and calmodulin-dependent protein kinase 4（Camk4）,play the crucial roles in reprogramming of the germ-cell genome,repression and activation of the downstream target genes,and germ-cell specific events,for example,germ cell development,regulation of meiosis,chromosome pairing and genomic integrity,and so on, during the germ-cell genesis and development. Herein, the research progress of the genesis and development of mammalian germ-cell, and their epigenetic regulation,were reviewed.
出处
《国际生殖健康／计划生育杂志》
CAS
2015年第2期136-140,共5页
Journal of International Reproductive Health/Family Planning
作者简介
通信作者：丁之德，E-mail：zding@shsmu．edu．cn,审校者
