摘要
目的：研究骨康胶囊辅助T型钢板内固定治疗桡骨远端骨折的临床疗效。方法：2012年1月~2013年12月在华中科技大学同济医学院附属普爱医院骨科经X线确诊的单纯性桡骨远端骨折老年患者108例随机分为观察组和对照组,两组患者均接受T型钢板内固定手术进行治疗,对照组患者手术当天开始口服碳酸钙片,观察组患者在服用碳酸钙的基础上服用骨康胶囊,4周为1个疗程。比较两组患者术后腕关节疼痛及肿胀程度,血清Ⅰ型前胶原羧基端肽（PⅠCP）和骨钙素（BGP）水平,并比较两组患者术后住院时间和骨折临床愈合时间以及术后6个月腕关节功能的恢复情况。结果：两组患者术前和术后28天时腕关节VAS评分差异无统计学意义（P〉0.05）,术后3、5、7、14、21天观察组腕关节VAS评分均较对照组显著降低（P〈0.01）;两组患者术前和术后28天时手背肿胀程度评分差异无统计学意义（P〉0.05）,术后3、5、7、14、21天观察组手背肿胀程度评分均较对照组显著降低（P〈0.01）;术前两组患者血清PⅠCP及BGP水平差异无统计学意义（P〉0.05）,术后1个月和2个月时观察组患者血清PⅠCP和BGP较对照组患者显著升高（P〈0.01）;观察组住院时间和骨折临床愈合时间均较对照组显著缩短（P〈0.05）;术后6个月观察组患者腕关节功能恢复有效率为79.63%,显著高于对照组（P〈0.05）。结论：骨康胶囊辅助T型钢板内固定治疗桡骨远端骨折具有良好的疗效,可降低患者术后疼痛及肿胀,升高血清PⅠCP和BGP水平,促进骨折愈合以及腕关节功能的恢复。
Objective： To study the clinical efficacy of supplementary treatment of Gukang Capsules to the elder patients with fracture of the distal radius. Methods： A total of 108 elder patients with fracture of the distal radius diagnosed by X-ray,who visited orthopedics department of Pu’ ai Hospital in January 2012 ~ December 2013,were randomly divided into observation group and control group. Cases in both groups received the operation of internal fixation by T-type plate. Cases in control group received oral Calcium Carbonate Tablets,and cases in observation group received Gukang Capsules besides Calcium Carbonate Tablets. Treatment duration was four weeks. The painful and swelling degree of wrist joints,levels of type Ⅰ propeptide carboxy-terminal procollagen（PⅠCP） and bone glaprotein（BGP） in serum were compared. Hospitalization and fracture healing time,as well as recovery condition of wrist joints in the sixth month after operation were compared. Results： The VAS of both groups was not significantly different before operation and in the28 th day after operation（P 〉 0. 05）,but the VAS in observation group was significantly lower than that in control group in the 3rd,5th,7th,14 th and 21 th day after operation（P 〈 0. 01）. The swelling scale of both groups was not significantly different before operation and in the 28 th day after operation（P 〉 0. 05）,but the swelling scale in observation group was significantly lower than that in control group in the 3rd,5th,7th,14 th and 21 th day after operation（P 〈 0. 01）. The levels of PⅠ CP and BGP in serum of both groups were not significantly different before operation（P 〉 0. 05）,but the levels of PⅠ CP and BGP in serum of observation groups were significantly higher than that in control group one and two months after operation（P 〈 0. 01）. Hospitalization and fracture healing time in observation group was significantly shortened compared with control group（P 〈 0. 05）. The effective ratio in observation group was 79. 63%,significantly higher than that in control group（P 〈 0. 05）. Conclusion： Gukang Capsules supplementary to internal fixation by T-type plate has favorable efficacy to fracture of the distal radius,which can reduce pain and swelling,increase levels of PⅠ CP and BGP in serum,as well as promote the heal of fracture and recovery of wrist joints function.
出处
《中药材》
CAS
CSCD
北大核心
2015年第1期193-196,共4页
Journal of Chinese Medicinal Materials
基金
武汉市卫生局科研项目(WX11C20)
关键词
骨康胶囊
桡骨远端骨折
Gukang Capsules
Fracture of the distal radius
作者简介
王威（1982-），男，在读博士研究生，专业方向；上肢骨科，手外伤；Tel：027-68835012。
