摘要
目的：探讨嗜酸性粒细胞和异常淋巴细胞在恙虫病中的表达情况及诊断意义。方法回顾性分析20例恙虫病患者，并对其血常规、血涂片等进行检测；另外选取健康体格检查者20名作为健康对照组，对照研究恙虫病患者异常淋巴细胞、嗜酸性粒细胞的表达；计量资料比较采用t检验。结果20例恙虫病患者中嗜酸性粒细胞减少18例（90％，18／20），其中嗜酸性粒细胞计数为0占80％（16／20）。异常淋巴细胞检出率95％（19／20），其在各种实验室检查中的检出率居首位。治疗前恙虫病组嗜酸粒细胞计数为（0．0035±0．008）×109／L，显著低于健康对照组（0．133±0．114）×109／L；治疗前异常淋巴细胞百分比为（5±4．22）％，显著高于健康对照组（0．05±0．224）％，差异均有统计学意义（P＜0．05）。经阿奇霉素治疗4～9天后，复查血常规及血涂片，嗜酸性粒细胞计数为（0．079±0．05）×109／L，异常淋巴细胞百分比为（0．25±0．78）％，与治疗前相比差异均有统计学意义（ P＜0．05）。异常淋巴细胞检出率下降至10％（2／20），与治疗前相比差异有统计学意义（P＜0．05）。结论嗜酸性粒细胞减少和异常淋巴细胞的检出率升高是恙虫病患者的重要临床特征之一，对恙虫病早期诊断具有一定的重要意义。
Objective To investigate the expression and diagnostic significance of acidophilic granulocyte and abnormal lymphocytes in the tsutsugamushi disease.Methods 20 cases of tsutsugamushi disease were retrospectively analyzed and examined their routine blood and blood smear;another 20 were selected of physical health inspectors as the control group, and next compare the two groups that eosinophils and abnormal lymphocytes express in tsutsugamushi disease patients; Measurement data were compared using t test. Results 20 cases of tsutsugamushi disease patients in eosinophils reduced 18 cases （ 90%, 18/20 ） , which there was 80%of eosinophil count was 0 （ 16/20 ） .The detection rate of abnormal lymphocytes was 95% （ 19/20）, and it was in the first place of various laboratory detection rate.Before treatment acidophilic granulocyte count of the tsutsugamushi disease group was （0.0035 ±0.008） ×109/L, which was significantly lower than the healthy control group （0.133 ±0.114） ×109/L; before treating abnormal lymphocyte percentage was （5 ± 4.22）%, which was significantly higher than the control group （ 0.05 ±0.224 ）%, the differences were statistically significant （P〈0.05）.Reviewing the routine blood and blood smear after 4 ～9 days of treatment with azithromycin, eosinophil counting （ 0.079 ±0.05 ） ×109/L and abnormal lymphocyte percentage being （0.25 ±0.78 ）%, it turned out that compared with pre-treatment the differences of them were statistically significant （P〈0.05）.And the detection rate of abnormal lymphocytes decreased to 10% （2/20）, compared with before treatment difference was statistically significant （ P 〈0.05 ）.Conclusions The reduction of eosinophils and increasing of detection rate of the abnormal lymphocytes is one of the important clinical features of the tsutsugamushi disease patients, which has some significance for the early diagnosis of the tsutsugamushi disease.
出处
《齐齐哈尔医学院学报》
2015年第8期1111-1113,共3页
Journal of Qiqihar Medical University
关键词
恙虫病
嗜酸性粒细胞
异常淋巴细胞
Tsutsugamushi disease
Eosinophils
Abnormal lymphocytes
作者简介
通信作者：李冬冬，Email：wonenngxing363@163．com
