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膝关节周围骨挫伤后关节软骨代谢物变化 被引量：5

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摘要 目的观察膝关节周围骨挫伤后膝关节液中Ⅱ型胶原羧基端端肽(CTX-Ⅱ)含量的变化。方法收集自2006-05—2012-05由MRI确诊单纯骨挫伤69例(骨挫伤组)、膝关节骨性关节炎61例(关节炎组)、下肢骨折髓内钉内固定45例(正常组)的膝关节液,采用免疫组化法对膝关节液中CTX-Ⅱ含量进行检测,评估骨挫伤后膝关节软骨代谢变化。结果骨挫伤组关节液中CTX-Ⅱ的含量为(69 492.67±101.87)ng/ml,关节炎组关节液中CTX-Ⅱ的含量为(61 484.00±301.60)ng/ml,正常组关节液中CTX-Ⅱ的含量为(45 169.42±105.32)ng/ml。骨挫伤组关节液中CTX-Ⅱ含量高于正常组,差异有统计学意义(t=6.456,P<0.001);但和关节炎组差异无统计学意义(t=2.228,P=0.315)。结论骨挫伤后膝关节液CTX-Ⅱ含量升高,可能与骨软骨急性损伤后出现降解有关,需要及时制动,避免进一步损伤造成创伤性关节炎。
作者 孙国静 李桂军 吴俊 王励芹 郭国栋 孟嘉 周利武 赵建宁
机构地区 南京军区南京总医院骨科 常州市第四人民医院骨科
出处 《中国骨与关节损伤杂志》 2015年第4期412-413,共2页 Chinese Journal of Bone and Joint Injury
基金 江苏省科技计划项目(BL2012002) 南京军区医药卫生科研基金课题(11Z028) 南京军区南京总医院课题(2012039)
关键词 膝关节骨性关节炎 Ⅱ型胶原羧基端端肽 关节滑液 骨软骨损伤
分类号 R683 [医药卫生—骨科学]
作者简介 通讯作者：赵建宁，E-mail：sugine@126．com
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参考文献9

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共引文献3

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引证文献5

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中国骨与关节损伤杂志
2015年 第4期

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