摘要
目的探讨体素内不相干运动成像(IVIM)在宫颈癌术前分级及放射治疗疗效评估中的可能性。方法回顾性分析23例手术治疗宫颈癌患者的影像学资料,应用双指数函数分别计算出高分化、中低分化两组的参数ADCstandard值、扩散系数D值、灌注系数D*值和灌注分数f值,进行统计学分析。12例宫颈癌放射治疗患者放射治疗前、后不同时间行盆腔IVIM检查,观察肿瘤组织在放射治疗前、后的形态及参数ADCstandard值、扩散系数D值、灌注系数D*值和灌注分数f值变化。结果宫颈癌手术患者高分化组10例,中低分化组13例,与高分化组比较,中低分化组的ADCstandard值、D值减低,组间均存在统计学差异(Z=-3.496、-2.660,P<0.05),ADCstandard值、D值的曲线下面积分别为0.965和0.854;D*和f值组间无统计学差异(t=-0.184、1.072,P>0.05);宫颈癌放射治疗患者放射治疗前、后肿瘤组织有不同程度缩小,D值增高,组间均存在统计学差异,(Z=-1.999,P<0.05),D值的曲线下面积分别为0.727,ADCstandard、D*和f值组间无统计学差异。结论体素内不相干运动扩散成像可以术前预测宫颈癌的高、中低分化程度,对放射治疗评价有一定意义。
Objective To investigate the feasibility of intravoxel incoherent motion （IVIM） for grading cervical cancer and evaluating effect of radiation treatment. Methods The imaging and pathological findings of 23 patients with cervical cancer were analyzed retrospectively. The standard apparent diffusion coefficient （ADCstandard）, diffusion coefficient （D）, perfusion coefficient （D＊） and perfusion score （f） on double exponential function analysis of well-and poorly-differentiated cancer were compared using t test. These parameters were also compared in 12 patients before and after radiotherapy. Results The ADCstandard and D values of 13 poorly-differentiated tumors were significantly lower than that of 10 well-differentiated tumors （Z=-3.496, -2.660, P〈0.05）. There was no significant difference in the areas under the curves of ADCstandard （0.965） and D （0.854）, D＊and f （t=-0.184, 1.072, P〉 0.05） between the two groups. Tumor size and D values were significantly reduced after radiotherapy （Z=-1.999, P〈0.05） whereas the areas under the D, ADCstandard, D＊and f value curves were not significantly different before and after treatment. Conclusions IVIM analysis is feasible for grading cervical cancer and assessing response of radiotherapy.
出处
《影像诊断与介入放射学》
2015年第1期54-58,共5页
Diagnostic Imaging & Interventional Radiology
关键词
磁共振成像
体素内不相干运动
扩散加权成像
宫颈癌
Magnetic resonance imaging
Intravoxel incoherent motion
Diffusion-weighted imaging
Cervical cancer
