摘要
目的探讨心肌梗死不同时间段基质细胞衍生因子-1（SDF-1）的含量与左心功能变化的相互关系。方法23只中华小型猪随机分为实验组及对照组，实验组开胸结扎冠状动脉左前降支制备急性心肌梗死模型并依据梗死后不同时间点随机分为6个亚组，分别行超声心动图检查，测量左室舒张末期内径（LVDd）、左室射血分数（LVEF）和左室短轴缩短率（LVFS），应用二维斑点追踪技术测量左室整体圆周应变（GCS）及整体径向应变（GRs）。各组实验终点动物处死后取相应心肌梗死组织应用实时荧光定量PCR法测定SDF-1含量。结果与对照组相比，各实验组心肌组织内SDF-1含量均明显升高，LVEF、LVFS、GCS和GRS均降低，LVDd明显增大。心肌组织内SDF-1含量和左室短轴乳头肌水平GCS有一定相关性（r=-0．580，P=0．000）。结论心肌组织内SDF-1的释放与GCS有一定相关关系。
Objective To investigate the relationship between the content of stromal cell-derived factor-1 （SDF-1） in myocardium in different period of myocardial infarction and left ventricular function. Methods Twenty-three Chinese miniature pigs were randomly divided into the experimental group and the control group. The swines in experimental group were prepared as acute myocardial infarction model by ligating anterior descending coronary artery and were randomly divided into 6 subgroups according to the different time points after infarction. The left ventricular end-diastolic diameter （LVDd）, left ventricular ejection fraction （LVEF） and left ventricular fraction shortening （LVFS） were measured respectively. Global circumferential strain （GCS） and global radial strain （GRS） of left ventricle were measured. The content of SDF - 1 were also measured by real-time quantitative PCR. Results Compared with the control group,SDF-1 levels were significantly elevated,and LVEF, LVFS,GCS and GRS were reduced. However, LVDd were significantly increased. The content of SDF-1 and GCS has a negative correlation （ r = - 0.580, P = 0.000）. Conclusions The content of SDF - 1 in myocardial tissue have a certain relationship with GCS of left ventricular myocardium.
出处
《中华超声影像学杂志》
CSCD
北大核心
2015年第3期254-257,共4页
Chinese Journal of Ultrasonography
基金
国家自然科学基金资助（81271590）
作者简介
通信作者：穆玉明，Email：mym1234@126．com
