摘要
目的分析突发性聋(sudden hearing loss,SHL)患者血脂代谢特点及血浆纤维蛋白原的水平,探讨其与突发性聋发病的相关性。方法 180例突发性聋患者(SHL组)根据纯音听阈曲线类型分为低中频下降组(低中频组)40例、高频下降组(高频组)90例、全频下降组(全频组)50例;另选取180例同期住院治疗、听力正常的鼻中隔偏曲、声带息肉患者作为对照组。检测各组对象的外周血甘油三脂(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、血糖(GLU)、血浆纤维蛋白原(FIB)的水平并行对比分析;对有意义的因素进行多因素Logistic回归分析。结果 SHL组(尤其是全频下降型和低中频下降型)TC、LDL-C、Glu、FIB高于对照组,HDL-C低于对照组,差异有统计学意义(P<0.05),TG与对照组差异无统计学意义(P>0.05);Logistic多因素分析显示LDL-C、FIB水平增高是突发性聋发病的主要相关危险因素。结论突发性聋患者血脂代谢异常,LDL-C和FIB水平增高是突发性聋发病的相关危险因素。
Objective Through the analysis of the characteristics of serum lipids metabolism and plasma fi‐brinogen levels in patients with sudden hearing loss ,to investigate the relationship between them with sudden deaf‐ness .Methods A retrospective analysis of 180 cases of patients with sudden deafness （SHL group） ,depending on the type of auditory threshold curve divided into low intermediate frequency drops group （low intermediate frequency group） and 40 cases ,the high frequency drop group （high frequency） 90 cases ,all frequency drop group （group all frequency） 50 cases ,and drawing 180 cases in the same period of hospitalization deviated septum ,vocal cord polyp patients as control group .All patients＇triglyceride （TG） ,total cholesterol （TC） ,low -density lipoprotein choles‐terol （LDL -C） ,high density lipoprotein cholesterol （HDL -C） ,glucose （Glu） ,plasma fibrinogen （FIB ） levels were analyzed .Then a meaningful factor multivariate Logistic regression analysis was made .Results There was a statistically significant difference between the two groups＇TC ,HDL -C ,LDL -C ,Glu ,and FIB（P〈0 .05） .There was no significant difference of TG （P〉0 .05） .There was a statistically significant difference between the groups＇all frequency and low frequency group and control group TC ,HDL -C ,LDL -C ,FIB（P〈0 .05） .There was no sig‐nificant difference between each group of Sudden deafness group and the high frequency group and control group （P〉0 .05） .The Logistic regression analysis showed that the LDL ,FIB was the major risk factors associated with the onset of sudden deafness .Conclusion Lipid levels in patients with sudden hearing loss is higher than that of in the normal hearing group .High levels of LDL - C and FIB have close correlations with the patients with sudden deafness ,and the related risk factors for the onset of sudden deafness ,according to threshold curve type ,should choose targeted treatment options .
出处
《听力学及言语疾病杂志》
CAS
CSCD
北大核心
2015年第2期156-159,共4页
Journal of Audiology and Speech Pathology
基金
连云港市卫生局立项基金(1001)资助
关键词
突发性聋
血脂代谢
纤维蛋白原
Sudden hearing loss
Serum Lipid metabolism
Fibrinogen
作者简介
鲍凤香，女，江苏连云港人，副教授，主任护师，主要从事耳聋的临床研究。（Email：bfx1998@163．com）
