摘要
抗生素耐药性是目前幽门螺杆菌(Helicobacter pylori,H.pylori)根除治疗失败的重要原因。对于提高临床治疗效果,在某一地区的人群中H.pylori耐药发生率也应考虑。高效、快速、准确地检测出H.pylori抗生素耐药性和及时监控群体耐药发生率对提高临床治疗效果具有重要意义。目前,H.pylori抗生素的耐药机制逐渐清楚,这有助于探索新的检测方法、尤其是核酸检测技术。该文总结了用于H.pylori根除治疗最常用抗生素的主要耐药机制,并着重回顾了H.pylori抗生素耐药的基因检测技术进展,以期对改进H.pylori抗生素耐药的分子诊断提供理论指导和实践借鉴。
Antibiotic resistance of Helicobacter pylori is the most important reason for failure of its eradication. Overall prevalence of related antibiotic resistance in the region should be also considered for an effective treatment. It is clinically important to detect H. pylori antibiotic resistance efficiently and monitor its incidence in local population timely. With the mechanisms of antibiotic resistance for H. pylori becoming clear gradually, more diagnostic methods, especially the molecular technologies come to the fore. In this review, the main resistance mechanisms of the most commonly used antibiotics in H. pylori eradication therapy were briefly discussed and the progresses in molecular diagnostic technologies were emphaticallysummarized, which may provide theoretical guidance and practical reference for molecular diagnosis of H. pylori antibiotic resistance.
出处
《分子诊断与治疗杂志》
2015年第2期132-139,共8页
Journal of Molecular Diagnostics and Therapy
基金
福建省科技厅重大项目(2012Y4009)
福建省自然科学基金(2011J01220)
福建省教育厅资助课题(JA09118)
厦门市科技计划(3502Z20123036)
中央高校基本科研业务费专项资金(12J0445*
13J0493*)
华侨大学引进人才科研启功费(12Y0317*)
泉州市科技项目(No.2010Z87)
关键词
幽门螺杆菌
抗生素耐药
基因检测
Helicobacter pylori
Antibiotic resistance
Resistance gene detection
作者简介
通讯作者：葛安国，E-mail：geanguo@126．com
通讯作者：王明席，E-mail：mxwang@hqu．edu．cn
通讯作者：胡伟鹏．E—mail：hwplcj@sina．com
