摘要
目的：探讨碘普罗胺注射液致药品不良反应的临床特点及发生规律，为降低临床用药风险提供参考。方法对1994年1月-2013年12月中国期刊全文数据库文献进行检索，对其中涉及碘普罗胺注射液致不良反应病例报告进行统计与分析。结果碘普罗胺所致不良反应男性和女性比例相当，年龄分布以40-59岁组最多，发生在1 h 内占87.72%，临床表现多样、过敏性休克最多、最为严重，死亡3例。结论为确保用药安全，用药前后应注意观察，对严重的不良反应应做到早识别、早干预，应严格遵循 SFDA 建议。
Objective To study clinic features and regularity of Adverse Drug Reaction（ADR） induced by iopromide injection, so as to provide a reference to reduce the risk of its use. Methods 57 ADR cases of iopromide injection are collected and analyzed statistically from CNKI articles from Jan. 1994 to Dec. 2013. Results In 57 patients, the ratio between male and female was 1：1. The ADR was mainly from the 40-59 age group. 87.72% of ADR induced by iopromide injection occurred in 1 hour. The clinical manifestations varied broadly, in which anaphylactic shock showed the highest incidence and the severest drug adverse reaction. Three patients eventually died of severe anaphylactic reaction. Conclusion In order to ensure the safe drug use, it is necessary to carefully monitor the occurrence of anaphylactic reaction, early recognition and intervention is also critical. Clinical use of iopromide injection should follow the SFDA recommendations strictly.
出处
《中国药物警戒》
2015年第3期169-171,共3页
Chinese Journal of Pharmacovigilance
关键词
碘普罗胺注射液
不良反应
分析
iopromide injection
adverse drug reactions
analysis
作者简介
刘生友，男，本科，主任药师，医院药学。
