摘要
目的观察苯磺酸氨氯地平与苯磺酸左旋氨氯地平对高血压患者短时血压变异性(BPV)影响的差异,明确高血压患者最佳钙离子通道拮抗剂治疗方案。方法连续入选心内科门诊首诊二级高血压患者共260例,将患者随机分为苯磺酸氨氯地平组130例和苯磺酸左旋氨氯地平组130例,均进行相应药物治疗共6个月。24 h动态血压监测测定收缩压、舒张压标准差、变异系数及血压晨峰评估BPV。两独立样本t检验比较组高血压患者BPV差异。结果与苯磺酸氨氯地平组相比,苯磺酸左旋氨氯地平组血压晨峰[(33.2±2.0)mm Hg比(31.8±2.1)mm Hg,P<0.001]、收缩压标准差[(8.35±1.30)mm Hg比(8.01±0.82)mm Hg]、收缩压变异系数[(0.083±0.011)比(0.079±0.012)]均明显升高(均P为0.012<0.05)。结论苯磺酸氨氯地平对高血压患者短时BPV,尤其是收缩压BPV及血压晨峰有明显改善作用。
Objective To observe effects of amlodipine besylate and levamlodipine besylate on short time blood pressure variability （ BPV）in hypertensive patients and determine the optimal calcium channel blocker（ CCB）therapeutic regimen for hypertensive patients. Meth-ods Two hundred sixty consecutive grade two hypertension patients at first visit were enrolled from Cardiac Clinic of our hospital. Patients were randomly divided into amlodipine besylate group（130 cases）and levamlodipine besylate group（130 cases）and underwent 6 months treatment. Systolic and diastolic blood pressure standard deviation,coefficient of variation and morning blood pressure surge（ MBPS）were measured by 24-h ambulatory blood pressure monitoring to assess BPV. Two independent sample t tests were performed to compare BPV difference of hypertensive patients in amlodipine besylate group and levamlodipine besylate group. Results Compared with amlodipine besylate group,in levamlodipine be-sylate group,MBPS（33. 2 ±2. 0 mmHg vs. 31. 8 ± 2. 1 mmHg,P ﹤0. 001）,systolic blood pressure standard deviation（8. 35 ±1. 30 mmHg vs. 8. 01 ±0. 82 mmHg,P ﹤0. 05）and systolic coefficient of variation（0. 083 ± 0. 011 vs. 0. 079 ±0. 012,P ﹤0. 05）were obviously higher. Con-clusion Amlodipine besylate can significantly reduce short time BPV,especially systolic BPV and MBPS in hypertensive patients.
出处
《临床和实验医学杂志》
2015年第5期378-380,共3页
Journal of Clinical and Experimental Medicine
作者简介
通讯作者：韩凌，E-mail：guzhouchen@126．com
