摘要
目的探讨全反式维甲酸联合三氧化二砷治疗初治成人急性早幼粒细胞白血病的疗效。方法选择2005年6月至2011年6月梅州市人民医院收治的初治成人急性早幼粒细胞白血病患者92例作为研究对象。按照治疗方法不同分为两组。观察组(46例)采用全反式维甲酸和三氧化二砷治疗,对照组(46例)仅采用全反式维甲酸治疗,对两组患者诱导缓解治疗间相关指标及相关预后指标进行比较。结果观察组和对照组诱导缓解期间相关指标完全缓解(CR)率、达CR时间、白细胞峰值、早期病死率、感染率及诱导治疗结束早幼粒细胞性白血病(PML)/维A酸受体(RAR)α融合基因转阴率进行比较,除早期病死率、感染率外,差异均有统计学意义(P<0.05);所有患者跟踪随访2年,观察组和对照组复发率、无病生存率、1年生存率及2年生存率比较,除1年生存率外,差异均有统计学意义(P<0.05)。结论联合全反式维甲酸及三氧化二砷联合治疗急性早幼粒细胞白血病诱导缓解治疗方案可以明显降低复发率、提高CR率及长期生存率。
Objective To explore the curative effect of all-trans retinoic acid and arsenic trioxide chemotherapy for acute promyelocytic leukemia. Methods A total of 92 patients with first adult acute promyelocytic leukemia admitted in Meizhou People＇s Hospital from Jun. 2005 to Jun. 2011 were selected as research objects,and divided into the observation group and the control group according to different methods of treatment,patients in observation group（ 46 cases） were treated by all-trans retinoic acid and arsenic trioxide,while patients in control group（ 46 cases） were only treated by all-trans retinoic acid. Related indexes during induced remission period and prognostic indicators of the two groups were compared. Results Among the related indicators of the two groups during induced remission period： complete remission（ CR） rate,time of CR,WBC peak value,early mortality rate,infection rate and PML / RARα overcast rate,except for early mortality and infection rates,differences of the other indicators between the two groups were statistically significant（ P 0. 05）; during the 2-year follow-up of all the patients,among the recurrence rate,disease-free survival rate,1-year survival rate,2-year survival rate,except for 1-year survival rate,differences of the other rates were statistically significant（ P 0. 05）. Conclusion All-trans retinoic acid and arsenic trioxide chemotherapy for acute promyelocytic leukemia can significantly reduce the recurrence rate,improve the CR rate and long-term survival rate.
出处
《医学综述》
2015年第2期365-366,共2页
Medical Recapitulate
关键词
早幼粒细胞白血病
全反式维甲酸
三氧化二砷
Acute promyelocytic leukemia
All-trans retinoic acid
Arsenic trioxide
