摘要
目的了解妊娠期亚临床甲状腺功能减退症的发病率及甲状腺素替代疗法的临床转归.方法通过分析早孕患者的资料,确诊妊娠合并亚临床甲状腺功能减退症,将患者按照是否接受甲状腺素替代治疗分为治疗组与对照组,治疗组168例,对照组69例,分析2组的妊娠结局.结果 5 455例妊娠女性在研究期间完成妊娠初期甲减筛查,237例妊娠女性被诊断为亚临床甲减,37例被诊断为临床甲减,19例被诊断为低T4血症,对于亚临床甲减孕妇,甲状腺素替代治疗组较对照组先兆流产等不良事件发生率明显低于对照组,P<0.01.结论对妊娠妇女早期进行甲状腺素筛查,早发现亚临床甲减孕妇,应用甲状腺素早期干预,可以降低临床不良事件的发生.
Objective To explore the incidence of subclinical hypothyroidism during pregnancy and the clinical outcome after thyroid hormone replacement therapy. Methods We retrospectively analyzed the data of the patients with early pregnancy, 237 cases were diagnosed subclinical hypothyroidism. According to whether the patients received thyroid hormone replacement therapy or not, the patients were divided into treatment group（168cases） and control group（69 cases）,and then we compared the clinical outcome. Results There were 5 455 cases enrolled in the study, and 237 cases were diagnosed with subclinical hypothyroidism, 37 cases with clinical hypothyroidism and 19 cases with hypothyroxinemia. In treatment group, the incidence of adverse pregnancy outcomes such as threatened abortion and so on were significantly lower than that in control group, the differences were statistically significant（P 〈0.01）. Conclusions Thyroid hormone replacement therapy can reduce the incidence of adverse pregnancy outcomes. This study suggests it is necessary to porform the thyroid function screening for the patients in early pregnancy.
出处
《昆明医科大学学报》
CAS
2015年第3期128-130,共3页
Journal of Kunming Medical University
作者简介
蔺瑾（1972-）女，云南昆明市人，医学学士，主治医师，主要从事妇产科临床工作．
