摘要
目的探讨伴t（11；19）（q23；p13．1）恶性血液病的临床及实验室特征。方法分析1例血液病患者资料，其骨髓细胞24h培养后按常规方法制备染色体，用R显带技术进行细胞遗传学分析。结果该例患者核型为t（11；19）（q23；p13．1），确诊为急性髓系白血病（AML）-M4c.应用MA方案化疗后患者未获完全缓解。结论t（11；19）（q23；p13．1）是一类很独特的白廊病亚型有关的易位，为少见的非随机染色体易位，其临床预后差。
Objective To investigate the clinical and laboratory characteristics of hematological malignancies with t（11;19）（q23;p13.1）. Methods Chromosome specimens of bone marrow cell from a patient with hematological malignancy were collected. After short-term cuhure, and chromosome karyotype analysis was carried out by R banding technique. Results The chromosome karyotype of the patient diagnosed with AML M4c was t （11;19）（q23;p13.1）. The patient did not obtain complete remission after application of MA regimen chemotherapy. Conclusions t（11;19）（q23;p13.1） translocation is a rare and recurring chromosome abnormality, which is related with a specific type of AML. The prognosis of the AML patients with this chromosome ahnormality is poor.
出处
《白血病．淋巴瘤》
CAS
2015年第1期58-60,共3页
Journal of Leukemia & Lymphoma
基金
国家自然科学基金（81100379）
关键词
染色体
易位
细胞遗传学
恶性血液病
Chromosome
Transloeation
Cytogenetics
Hematological malignancies
作者简介
通信作者：谭丽，Email：tanya4662@sina．com
