摘要
目的分析2000-2011年广州市城区甲状腺癌的发病情况及变化趋势。方法利用广州市肿瘤登记处2000-2011年广州市城区甲状腺癌的发病和人口资料，共计2957例，覆盖人口45699522人年，其中男性649例，覆盖人口23391743人年，女性2308例，覆盖人口22307779人年，计算分析不同年度、年龄段的粗发病率、中国人口结构标化发病率（中标发病率）、世界人口构成标化发病率（世标发病率）和发病年度变化百分比（APC），分析各性别和年龄段发病率的变化趋势。结果2000-2011年广州市城区居民甲状腺癌发病共2957例，男女发病患者例数比为1：3．56，世标发病率从2000年的2．99／10万上升到2011年9．13／10万，增加了204．73％，APC为10．5％（P〈0．001）；男性的世标发病率从2000年的1．32／10万上升到2011年的3．54／10万，增加了169．45％，APC为8．6％（P〈0．001）；女性世标发病率从2000年的4．73／10万上升到2011年的14．87／10万，增加了214．64％，APC为10．9％（P〈0．001）。男性和女性甲状腺癌发病年龄有较大差别，女性45～59岁为发病高峰，为19．56／10万，男性发病率则随着年龄增长逐步增加，由15～19岁的0．74／10万增加到85岁以上组的9．48／10万。20～59岁年龄组男、女性APC分别为12．2％、13．4％，差异均有统计学意义（P〈0．001）。结论甲状腺癌发病呈逐年上升趋势，20～59岁年龄组人群是甲状腺癌防治的重点人群。
Objective To investigate the incidence and trends of thyroid cancer in urban areas of Guangzhou,2000- 2011. Methods Total of 2 957 new cases with a coverage population of 45 699 522 person-years diagnosed as thyroid cancer in 2000 -2011 in urban areas of Guangzhou were extracted from the population-based data base of Guangzhou cancer registry, among which 649 were males and 2 308 were females with a coverage population of 23 391 743 person-years and 22 307 779 person-years,respectively. The crude incidence, Chinese age-adjusted incidence rate and world age-adjusted incidence rate were calculated. Time trends of different gender and age groups Were examined using Joinpoint Regression Program. Results There were a total of 2 957 cases diagnosed as thyroid cancer during 2000 -2011 with a sex ratio of 1 ： 3.56. World age adjusted incidence rates of thyroid cancer in urban areas of Guangzhou increased dramatically from 2. 99/100 000 in 2000 to 9. 13/100 000 in 201l with an increase rate of 204.73%. Annual percentage change （APC）was 10. 5% （P 〈 0. 001 ）. The APC in world age adjusted incidence rates of thyroid cancer were 8.6% （ P 〈 0. 001 ） for male and 10. 9% （ P 〈 0. 001 ） for female, rcsuhing in a total increase of 169.45% （from 1.32/100 000 to 3.54/100 000） for male and 214. 64% for temale（from 4. 73/100 000 to 14. 87/100 000）. The mean age of onset of thyroid cancer was significantly different between the males and females. The incidence rate of thyroid cancer in females aged 45 - 59 group （19. 56/100 000） reached the highest one. While in males, it was increasing gradually with the age, the incidence increased from 0.74/100 000 in aged 15 - 19 to 9.48/10 000 in aged of 85 years above. The APC was significant in 20 - 59 age groups in both males（12.2%） and females（13.4%） （P 〈 0.001）.Conclusions The incidence rate of thyroid cancer increased rapidly in urban areas of Guangzhou. The prevention and treatment of thyroid cancer should be focused on 20 -59 age groups.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2015年第2期142-146,共5页
Chinese Journal of Preventive Medicine
关键词
甲状腺肿瘤
流行病学
发病率
横断面研究
Thyroid neoplasms
Epidemiology
Incidence
Cross-sectional studies
作者简介
通信作者：吴娴波，Email：wxb70@126．com
