摘要
目的：探讨病理T1（p T1）期的非小细胞肺癌（NSCLC）淋巴结转移的相关因素。方法：对我院胸外科1997年1月~2013年12月术后病理证实为p T1期且直径≤3cm的NSCLC患者进行回顾性分析。所有统计分析均采用SAS 9.13软件。结果：共入组p T1-NSCLC患者165例,其中男88例、女77例。平均年龄59岁（26~80岁）。发生N1淋巴结转移的比率为19.4%;发生N2淋巴结转移的比率为13.9%;发生N1＋N2淋巴结转移的比率为24.2%。单因素分析显示临床N（c N）分期、临床（c）分期及分化程度与N1、N2、N1＋N2淋巴结转移有相关性（P〈0.01）;临床T（cT）分期、病理类型及p T大小与N2淋巴结转移具有相关性（P〈0.05）。多因素分析显示仅c N分期与N1、N2、N1＋N2淋巴结转移存在相关性（P〈0.01）。结论：对于直径≤3cm的NSCLC而言,c N分期与纵隔及肺门、肺内淋巴结转移存在密切关系。肿瘤的病理类型、大小及分化程度与纵隔淋巴结及肺门、肺内淋巴结转移没有相关性。
Objective：To explore the predictive factors that related to lymph node（LN）metastasis of non-small cell lung cancer（NSCLC）.Methods：We studied patients undergone lobectomy and systemic LN dissection for pT1-NSCLC with diameter less than 3cm.Results：One hundred and sixty-five pT1-NSCLC patients were enrolled,including 88 men and 77 women.The average age was 59 years old.LN metastatic ratios were 19.4%,13.9% and 24.2% for N1,N2 and N1 ＋N2 LN respectively.Univariate analysis showed that c N stage,c stage and differentiation of cancer were related to N1,N2 and N1＋N2 LN metastasis.The c T stage,pathological type and p T size were related to N2 LN metastasis.Multivariate regression analysis showed that only c N stage was associated with LN metastasis.Conclusion：For patients of NSCLC with cancer diameter less than 3cm,only clinical N stage was related N1,N2 and N1＋N2 LN metastasis.
出处
《中日友好医院学报》
2015年第1期15-18,30,共5页
Journal of China-Japan Friendship Hospital
关键词
非小细胞肺癌
淋巴结转移
N分期
non-small cell lung cancer
lymph node metastasis
node stage
作者简介
张真榕（1982-），男，主治医师，医学博士。
通讯作者。
