摘要
目的探讨胆汁内外引流术对梗阻性黄疸（OJ）大鼠肝脏肿瘤特异性生长因子（TSGF）和糖类肿瘤相关抗原（CA 19-9）表达的影响。方法采用改良方法制备OJ、胆汁内引流组（ID）、胆汁外引流组（ED）和假手术组（SH）共120RSD大鼠模型，采用快速检测试剂盒检测大鼠肝脏TSGF和CA19-9水平，采用t检验、关联性分析等比较组间差异及其生物学意义。结果SH组的TB、ALT、AST水平最低，ID次之，ED及OJ组的TB、ALT、AST水平均高于SH、ID组，差异均有统计学意义（P〈0．05）；SH组的ALB最高，ID次之，ED组再次，OJ组最低（P〈0．05）；SH组的TSGF及CA19．9水平最低，ID次之，ED及OJ组最高，差异均有统计学意义（P〈0．05）；TSGF及CA19-9与TB呈正相关关系，与ALB呈负相关关系（P〈0．05）。结论胆汁内外引流术可有效缓解梗阻性黄疸大鼠的胆汁淤积状况，明显改善大鼠的肝功能．降低由此诱发的肿瘤危险性；相同的条件下，胆汁内引流效果更佳。
Objective To investigate the effects of internal and external biliary drainage on the expression of Tumor Supplied Group of Factors （ TSGF ） and tumor-associated carbohydrate antigen （ CA 19-9 ） of rat model of obstructive jaundice. Methods Rat models of Obstructive jaundice （ OJ ） , the biliary drainage group （ ID ） , biliary drainage group （ ED ） and sham group （ SH ） were made and TSGF and CA 19-9 levels were detected for analysis. Results TB, ALT, AST of SH groups were the lowest, ID followed （ P〈0.05 ） ; ALB of SH group was the highest, ID followed （ P〈0.05 ） ; TSGF SH group and the lowest levels of CA 19-9, ID followed, ED and maximum OJ group, the differences were statistically significant （ P〈0.05 ） ; TSGF and CA 19-9 were positively correlated with TB, but with ALB negatively （ P〈0.05 ） . Conclusions Internal and external drainage of bile can effectively alleviate the situation obstructive jaundice cholestatic rats, significantly improve the liver function in rats, thus reducing the risk of induced tumors; under the same conditions, the biliary drainage was better.
出处
《浙江临床医学》
2015年第2期171-173,共3页
Zhejiang Clinical Medical Journal
基金
湖北省沧州市科学技术研究与发展指导计划（1213016ZD）
作者简介
通讯作者
