摘要
目的探讨胸腔积液及血清中瘦素(LEP)、癌胚抗原(CEA)、肿瘤坏死因子-a(TNF-a)、白细胞介素-6(IL-6)及C反应蛋白(CRP)在诊断鉴别肺癌及肺结核疾病中的临床价值。方法 2013年6月至2014年6月选取60例肺结核及60例肺癌患者为研究对象,分别应用酶联免疫法及免疫比浊法分别测定两组患者血清及胸腔积液中LEP、CEA、TNF-a、IL-6及CRP水平。结果肺癌组患者胸腔积液、血液中LEP、CEA、TNF-a水平均高于肺结核组(P<0.05),而IL-6水平低于肺结核组(P<0.05),两组血清及胸腔积液中CRP水平均无统计学差异(P>0.05)。血清及胸腔积液中4种相关因子联合检测灵敏性、特异性、阳性预测值、阴性预测值与各单项相比差异有统计学意义(P<0.05)。结论肺癌患者血清及胸腔积液中LEP、CEA、TNF-a水平均高于肺结核组,而IL-6水平则低于肺结核组。通过联合检测可提高相关因子的诊断灵敏性,有助于肺癌及肺结核患者的鉴别诊断。
Objective To investigate the clinical value of investigate pleural effusion and serum leptin （LEP）,carci-noembryonic antigen （CEA）,tumor necrosis factor-a （TNF-a）,interleukin-6（IL-6）and C-reactive protein （CRP）in the differential diagnosis of lung cancer and pulmonary diseases.Methods The levels of LEP,CEA,TNF-a,IL-6 and CRP in serum and pleural effusion of 60 cases of tuberculosis and 60 cases of lung cancer patients were measured with ELISA and immunonephelometry.Results The levels of LEP,CEA,TNF-a in serum and pleural effusion of lung canc-er were higher than tuberculosis group （P〈0.05）,while the levels of IL-6 of Tuberculosis group were lower than tu-berculosis groups（P〈0.05）,the levels of CRP in serum and pleural statistically were significant difference （P〉0.05）. The factor sensitivity,specificity,positive predictive value,negative predictive value of serum and pleural effusion were hihger than those in the single （P〈0.05）.Conclusion The levels of pleural effusion LEP,CEA,TNF-a of patients with lung cancer were higher than the tuberculosis group,but lower than the level of IL-6 were lower than tuberculosis group.Through joint detection can improve the diagnostic sensitivity of the relevant factors to help in the differential di-agnosis of lung cancer and tuberculosis patients.
出处
《中国实验诊断学》
2014年第12期1993-1996,共4页
Chinese Journal of Laboratory Diagnosis
基金
南京医科大学科技发展基金(编号:2012NJMU238)
作者简介
通讯作者
