摘要
目的:探讨急性白血病(AL)患者血中α-羟丁酸脱氢酶(α-HBDH)与乳酸脱氢酶(LDH)的检测及临床意义。方法:选取入住本院的急性白血病患者82例作为AL组,另选取健康体检者65例作为对照组,检测两组研究对象的α-HBDH、LDH含量变化并进行比较。结果:AL初发或复发患者治疗前和对照组α-HBDH、LDH含量相比,差异有统计学意义(P<0.05);且其治疗前α-HBDH、LDH含量明显升高。治疗后,完全缓解者、部分缓解者、未缓解者α-HBDH、LDH含量比较,差异有统计学意义(P<0.05);完全缓解者、部分缓解者治疗前后α-HBDH、LDH含量比较,差异均有统计学意义(P<0.05);且治疗后α-HBDH、LDH含量均明显下降,未缓解者治疗前后α-HBDH、LDH含量比较,差异无统计学意义(P>0.05);AL复发患者复发前后α-HBDH、LDH含量比较,差异均具有统计学意义(P<0.05);复发后α-HBDH、LDH含量均明显升高。结论:动态监测血清α-HBDH和LDH的变化对AL患者的病情变化、疗效和判断预后具有重要的临床指导意义。
Objective： To investigate the detection and clinical significance of serum α-hydroxybutyrate dehydrogenase and lactic dehydrogenase in patients with acute leukemia. Methods：82 patients with acute leukemia as AL group were selected as AL group, and 65 healthy volunteers were selected as control group, content of α -HBDH, LDH were compared between the two groups in the. Results：There was significant difference between the AL primary or recurrent patients before the treat- ment and the control group in the content of α-HBDH, LDH（P〈0.05）, and the content of α -HBDH, LDH significantly in creased in the AL primary or recurrent patients before the treatment. After the treatment, there were statistically significant difference in the content of α-HBDH, LDH among the complete remission group, partial remission group, and no remission group（P〈0.05）, there were also statistically significant difference in the content of α-HBDH, LDH before and after the treat- ment between the complete remission group and the partial remission group（P〈0.05）, the content of α -HBDH, LDH bothdecreased in the two group, there was no statistically significant difference in the no remission group before and after the treat- ment（P〉0.05）, there was statistically significant difference in the content of α -HBDH, LDH between the AL patients before the recurrent and after（P〈0.05）. Conclusion： The dynamic detection of the levels of serum α-HBDH and LDH has important clinical significance and it may contribute to observe the changes of diseases process in AL patients, curative effect and progno- sis assessment.
出处
《海南医学院学报》
CAS
2014年第12期1742-1744,共3页
Journal of Hainan Medical University
基金
首都医学发展基金(2012-1098)~~
关键词
白血病
急性
Α-羟丁酸脱氢酶
乳酸脱氢酶
Leukemia
Acute
α-hydroxybutyrate dehydrogenase
Lactic dehydrogenase
作者简介
张越（1981-），女，硕士，电话：13552370700，电子邮箱：zhangyue6354@163．com.
[通讯作者]周合冰（1967-），女，硕士，主任医师，主要从事血液病的诊断及治疗工作。
