摘要
目的研究氟伐他汀对心肌梗死(AMI)大鼠基质金属蛋白酶(MMP-9、MMP-10)表达的影响,以探讨他汀类药物改善急性心肌梗死后心室重构的机制。方法 Wistar雄性大鼠随机分为假手术组、心肌梗死组、氟伐他汀组各12只,后两组均建立左冠状动脉前降支心肌梗死模型,氟伐他汀组于制模成功后予氟伐他汀灌胃6周,测左心室血流动力学参数、左心室重构指数及MMP-9、MMP-10表达的变化。结果与假手术组比较,心肌梗死组和氟伐他汀组大鼠左心室收缩压、左心室压最大上升速率及左心室压最大下降速率均明显下降(P<0.05),且心肌梗死组较氟伐他汀组下降更明显(P<0.05)。与假手术组比较,心肌梗死组和氟伐他汀组左心室舒张期末内径(LVEDD)和左心室收缩期末内径(LVESD)均显著增加,左心室射血分数(LVEF)均显著降低(P<0.05),心脏组织MMP-9、MMP-10表达明显增强(P<0.01);与心肌梗死组相比,氟伐他汀组LVEDD、左心室质量指数(LVMI)均降低,心脏组织MMP-9、MMP-10表达明显降低(P<0.01),LVEF显著增加(P<0.05)。结论氟伐他汀能逆转心室重构,其作用机制可能与抑制MMP-9、MMP-10的表达有关。
Aim To study the effect of fluvastatin on cardiac remodeling and cardiac function,and to investigate the effect of matrix metalloproteinase-9（MMP-9） and MMP-10. Methods 36 Wistar rats were randomly divided into acute myocardial infarction（AMI） group,AMI ＋ fluvastatin group and the sham-operated group. AMI was established by ligation of the anterior descending coronary artery in rats,fluvastatin was fed to AMI ＋ fluvastatin group by 20 mg /（ kg·d） for 6 weeks. After 6 weeks treatment,then the hemodynamic parameters and mass index of left ventricular and the expression of MMP-9 and MMP-10 were detected. Results Compared with the sham-operated group,left ventricular systolic pressure（LVSP） and the maximal rate of rise and fall（ ± dp /dtmax） of left ventricular pressure in the AMI group and AMI ＋ fluvastatin group were all decreased（ P 〈 0. 05）,moreover,these indexes decreased significantly in AMI group than those in AMI ＋ fluvastatin group（P 〈 0. 05）. Compared with the sham-operated group,left ventricular end-diastolic diameter（LVEDD）,left ventricular end systolic diameter（ LVESD）,left ventricular mass index（ LVMI）,MMP-9,MMP-10 were significantly increased in the AMI group and AMI ＋ fluvastatin group; moreover,these indexes decreased in AMI ＋ fluvastatin group than those in AMI group（P 〈 0. 05）. Conclusion Fluvastatin could prevent the cardiac remodeling,the mechanisms may be by reducing the levels of MMP-9 and MMP-10.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2014年第9期917-920,共4页
Chinese Journal of Arteriosclerosis
基金
山东省自然科学基金(ZR2010HM116)
关键词
心肌梗死
心室重构
氟伐他汀
基质金属蛋白酶9
基质金属蛋白酶10
Acute Myocardial Infarction
Ventricular Remodeling
Fluvastatin
Matrix Metalloproteinase-9
Matrix Metalloproteinase-10
作者简介
王士凯，硕士研究生，主要研究方向为心血管疾病的诊断和治疗，E-mail为shikaiwang@sina．com。
通讯作者梁江久，博士研究生导师，主要从事冠心病、心律失常的临床及基础研究，E-mail为liangjiangjiu@163．com。
