摘要
目的：对比观察小剂量胰岛素持续静脉滴注和胰岛素泵持续皮下输注胰岛素两种胰岛素给药方法治疗糖尿病酮症酸中毒（DKA）的临床疗效。方法选择2012年3月～2014年2月我院急诊科收治的糖尿病酮症酸中毒患者60例，用随机数字表法将患者分为观察组和对照组，每组30例。对照组采用小剂量胰岛素持续静脉滴注，观察组采用胰岛素泵持续皮下输注胰岛素，对比观察两组治疗后空腹血糖以及低血糖发生例数、血糖达标时间、尿酮体转阴时间以及胰岛素用量。结果治疗后两组空腹血糖比较差异无统计学意义（P＞0.05）；观察组血糖达标时间和尿酮体转阴时间均短于对照组，差异有统计学意义（P＜0.05）；观察组无低血糖患者发生，对照组共5例患者出现低血糖，两组比较差异有统计学意义（P＜0.05）；治疗后观察组胰岛素用量显著少于对照组，差异有统计学意义（P＜0.05）。结论胰岛素泵持续皮下输注胰岛素治疗更能快速、有效纠正糖尿病酮症酸中毒患者代谢紊乱，降低低血糖发生风险，减少胰岛素用量，临床疗效显著，值得积极推广。
Objective To observe the clinical effects betwee small doses of insulin intravenous drip continuously and Insulin pump continuous subcutaneous insulin infusion treated on diabetic ketoacidosis patients. Methods Selected 60 diabetic ketoacidosis patients in our hospital emergency department from March 2012 - February 2014, they were divided into observation group and control group according to the random number table method, 30 cases in each group. Patients in control group were treated with small doses of insulin intravenous drip continuously, while patients in observation group were treated with Insulin pump continuous subcutaneous insulin infusion.Observed the fasting plasma glucose after treatment, The cases of hypoglycemia,the time of blood glucose controlled and urine acetone bodies turned and Insulin dosage. Results There was no significant difference between two groups in fasting plasma glucose after treatment（P 〉 0.05）; the time of blood glucose controlled and urine acetone bodies turned in observation group were much shorter than in control group, the difference was statistically significant（P〈0.05）;There was no hypoglycemia in observation group, while there were 5 case hypoglycemia in control group, the difference was statistically significant（P〈0.05）;The Insulin dosage in observation group were much less than in control group,the difference was statistically significant（P〈0.05）. Conclusion Insulin pump continuous subcutaneous insulin infusion therapy can more quickly and effectively correct metabolic disorder in patients with diabetic ketoacidosis, reduce the risk of hypoglycaemia, reduce the dosage of insulin, the clinical curative effect is distinct, to actively promote.
出处
《中国医药科学》
2014年第24期62-64,共3页
China Medicine And Pharmacy
