摘要
以六氟异丙醇体积分数为50%的乙酸溶液为溶剂,制备I型胶原/聚氧化乙烯(PEO)复合静电纺微纳米纤维,研究了PEO质量分数对静电纺纤维形貌的影响,测试了不同胶原/PEO质量比(m(胶原)∶m(PEO))时的纺丝液黏度和电导率.采用扫描电镜、红外光谱、X射线衍射、热重分析对胶原/PEO复合纤维进行表征.结果表明,PEO的加入使纺丝液黏度增大,电导率减小,可有效提高胶原的可纺性.当m(胶原)∶m(PEO)为70∶30时,纤维形貌良好,平均直径为(267±45)nm.复合静电纺纤维中胶原与PEO分子链间存在一定的分子间作用力,但并没有改变彼此的化学结构.通过静电纺制备的胶原/PEO复合微纳米纤维膜由于其特有的结构和功能性,有望应用于伤口敷料和组织工程等生物医用领域.
Electrospun composite fibers of collagen（type-I）and polyethylene oxide（PEO）polymers were prepared using a solution of 1,1,1,3,3,3-hexafluoroisopropanol（HFIP）and acetic acid（AA）（VHFIP∶VAA=1∶1）.The viscosity and electrical conductivity of the electrospinning solution at different mass ratio of collagen to PEO（m（collagen）∶m（PEO））were tested.The influence of PEO mass fraction on the morphology and characteristics of the composite fibers were investigated using Scanning electron microscopy（SEM）, Fourier-transform infrared spectra（FTIR）, X-ray diffraction（XRD）and thermogravimetric（TGA）analyses.Addition of PEO in collagen dispersion showed lower electrical conductivity and higher viscosity,which subsequently resulted in improving spinning performance of the composite dispersion.Satisfactory morphology fibers with an average diameter of（267±45）nm were obtained when m（collagen）∶m（PEO）was 70∶30.The results indicated that the molecular interaction should exist between collagen and PEO,and suggested no major chemical structural changes occurred in these two polymers.Due to the particular microstructure and functions,the collagen/PEO composite fiber films would have potential applications in wound healing,tissue engineering and other areas.
出处
《东华大学学报（自然科学版）》
CAS
CSCD
北大核心
2014年第6期739-743,772,共6页
Journal of Donghua University(Natural Science)
基金
上海市科委支撑计划资助项目(14441901600)
作者简介
陈燕（1989-），女，浙江杭州人，硕士研究生，研究方向为生物医用纺织材料．E—mail：chenyan_ys@126．com
王璐（联系人），女，教授。E-mail：wanglu@dhu．edu．cn
